Antidyskinetic agent | definition of antidyskinetic agent by Medical dictionary
a functional category of drugs with anticholinergic action, used to treat Parkinson disease and some of the acute movement disorders that may be caused by antipsychotic agents.
an·ti·dys·ki·net·ic a·gent (an'tē-dis-ki-net'ik ā'jĕnt)
A functional category of drugs with anticholinergic action, used to treat parkinsonism and some acute movement disorders that may be caused by antipsychotic agents.
References in periodicals archive
Buspirone is a combined 5-hydroxytryptamine-1A (5-HT1A) and a1 adrenergic receptor agonist with antidyskinetic potential.[sup] Results of a dose-finding study suggested the suitability of buspirone for use as antidyskinetic agent
in PD.[sup] A Phase I study assessing the efficacy of buspirone (in combination with amantadine) and a Phase III (monotherapy) are actively ongoing.[sup],
* Start a trial of an adjunctive putative antidyskinetic agent
such as vitamin E
Hypotheses proposed to explain TD pathophysiology and thereby justify trials of specific antidyskinetic agents
include dopamine receptor hypersensitivity, GABA insufficiency, and structural damage resulting from increased catecholamine metabolism and oxidative free radical production.