Nobrega, "Contribution of decreased serotonin release to the antidyskinetic
effects of deep brain stimulation in a rodent model of tardive dyskinesia: comparison of the subthalamic and entopeduncular nuclei," Journal of Neuroscience, vol.
There have been several reports on the antidyskinetic
effects of amantadine, a nonselective NMDA receptor antagonist.[sup],, Amantadine has been approved for the treatment of LID despite its side effects such as confusion, constipation, and visual hallucinations.
treatment with MTEP affects multiple molecular pathways in the Parkinsonian striatum.
elata extract revealed better antidyskinetic
effects than those observed with amantadine, a reference drug (Doo et al., 2014).
Implication of NMDA receptors in the antidyskinetic
activity of cabergoline, CI-1041, and Ro 61-8048 in MPTP monkeys with levodopa-induced dyskinesias.
* Start a trial of an adjunctive putative antidyskinetic
agent such as vitamin E
Recently, there has been a renewed interest in its use after discovery of its antidyskinetic
(1-3) The pathophysiology of the antidyskinetic
properties of atypical antipsychotics, as well as the pathophysiology of tardive dyskinesia itself, remains unclear.
In what investigators termed an "unexpected" finding, concurrent use of amantadine also had a significant association with regurgitation (adjusted incidence rate ratio 3.5 (95% confidence interval 1.1-11.3), although they said the role of this antiviral / antidyskinetic
medication "requires further investigation."
They concluded, as we do, that the antidyskinetic
effect of amantadine lasts at least 1 year.
Recently, cannabinoid receptors activation has been reported to have neuroprotective and antidyskinetic
effects on animal models [83-85].
Finally, decide whether a trial of an adjunctive antidyskinetic
drug is warranted.