sup], A favorable antidyskinetic
outcome was reported in a study using a NR2B-selective NMDA glutamate antagonist, CP-101, 606; however, adverse cognitive effects were observed.
elata extract revealed better antidyskinetic
effects than those observed with amantadine, a reference drug (Doo et al.
Implication of NMDA receptors in the antidyskinetic
activity of cabergoline, CI-1041, and Ro 61-8048 in MPTP monkeys with levodopa-induced dyskinesias.
Interestingly, both agonists suppressed GID in parkinsonian rats at doses unable to affect LID in dyskinetic 6-OHDA-lesioned (nongrafted) rats, suggesting that foetal VM grafts induce a striking enhancement of the antidyskinetic
effect induced by DA receptor blockade .
Start a trial of an adjunctive putative antidyskinetic
agent such as vitamin E
Recently, there has been a renewed interest in its use after discovery of its antidyskinetic
1-3) The pathophysiology of the antidyskinetic
properties of atypical antipsychotics, as well as the pathophysiology of tardive dyskinesia itself, remains unclear.
3), although they said the role of this antiviral / antidyskinetic
medication "requires further investigation.
They concluded, as we do, that the antidyskinetic
effect of amantadine lasts at least 1 year.
The robust antidyskinetic
efficacy of these compounds was confirmed by three independent laboratories.
Finally, decide whether a trial of an adjunctive antidyskinetic
drug is warranted.
26] Whether apomorphine has a true pro- or antidyskinetic
effect remains to be determined.