Souli et al., "Antidiarrheal
and antioxidant activities of chamomile (Matricaria recutita L.) decoction extract in rats," Journal of Ethnopharmacology, vol.
The study of antidiarrheal
effect was carried out by using white albino mice, with body weight of 34 to 37 grams.
Mice were placed in separate boxes with clean paper for antidiarrheal
Biological screening of traditional preparations from medicinal plants used as antidiarrheal
in Kinshasa, Congo.
Exploration of the influence of nonantimicrobial antidiarrheal
agents with only antisecretory effect, such as racecadotril, as monotherapy and in combination with AMDs would also be beneficial.
Exclusion criteria were pregnancy or breastfeeding, unwillingness to stop antidiarrheal
medication, prior abdominal surgery other than appendectomy or cholecystectomy, or being in another trial.
Scientifically it has been reported to possess many pharmacological activity including antidiabetic, cardioprotective, antidiarrheal
and antibacterial properties [19, 3, 1].
A wide variety of medicinal properties are attributed to this plant, including anti-inflammatory (MOREIRA et al., 2011; ORLANDI et al., 2011), anti-ulcer (SANNOMIYA et al., 2007; SANTOS et al., 2012), gastroprotective (SANTOS et al., 2009, 2012), healing (SANTOS et al., 2009), duodenal antimicrobial and antidiarrheal
effects (SANTOS et al., 2012).
If vomiting is severe, medications can reduce it, but experts advise against taking an antidiarrheal
drug such as Lomotil or Imodium, which can prolong the infection.
Prior treatments that had failed in these patients included a gluten-free diet, systemic steroids or budesonide, antidiarrheal
agents, pancreatic enzymes, bile acid sequestrants, metronidazole, azathioprine, and octreotide.
It is commonly used for medicinal purposes in view of its antidiarrheal
and digestive properties.
This study involved evaluation of the antidiarrheal
activity of the ethanolic fruit extract of Psidium guajava in castor oil induced diarrhea in albino rats using loperamide as positive control, determined its acute toxicity in mice and its phytochemical composition.