Currently available interventions include aluminum chloride, which often helps insufficiently or is irritating; systemic anticholinergic agents
, which can have intolerable side effects like dry mouth; or botox injections, which are temporary, painful, and expensive.
Fesoterodine is an anticholinergic agent
comparable to darifenacin, with similar mechanism of action and advertised therapeutic effects.
Scopolamine hydrobromide, an anticholinergic agent
, is approved by the Food and Drug Administration for the prevention of nausea and vomiting associated with motion sickness and recovery from anesthesia and surgery.
If an anticholinergic agent
reaches the CNS, the potential for cognitive impairment is a function of the extent to which the agent blocks [M.sub.1] receptors.
This bronchoconstriction was significantly reduced (% inhibition) after pretreatment with the glucocorticosteroid budesonide (49%), the [[beta].sub.2] adrenergic agent albuterol (71%), the anticholinergic agent
atropine (58%), and the histamine [H.sub.1]-antagonist diphenhydramine (47%).
But treatment with an inhaled anticholinergic agent
is still a good option for COPD patients who do not have a history of cardiovascular disease or another condition that potentially could be worsened by these drugs, commented Dr.
However, concomitant use of an intranasal corticosteroid and an intranasal anticholinergic agent
such as ipratropium bromide can be more effective for rhinorrhea than either drug alone.
Conflicting results have been found on the question of whether the bronchodilator effect of [beta] agonists is increased by adding an anticholinergic agent
, in either COPD or asthma.
(1-3) An alternative agent is the short-acting anticholinergic agent
ipratropium bromide, which is sometimes used either on its own or in combination with SABA.
Delivers 3.9 mg daily of the antispasmodic anticholinergic agent
Undoubtedly, if a patient with OAB is successfully managed with behavioural therapy and a single first-line anticholinergic agent
, the cost to the health care system is less than repeated treatments with BTX A.
* Overdose with an anticholinergic agent
such as an antihistamine (for example, diphenhydramine), or an ingestion of an anticholinergic plant (such as deadly nightshade or Jimson weed) or an anticholinergic mushroom.