Currently available interventions include aluminum chloride, which often helps insufficiently or is irritating; systemic
anticholinergic agents, which can have intolerable side effects like dry mouth; or botox injections, which are temporary, painful, and expensive.
Fesoterodine is an
anticholinergic agent comparable to darifenacin, with similar mechanism of action and advertised therapeutic effects.
Scopolamine hydrobromide, an
anticholinergic agent, is approved by the Food and Drug Administration for the prevention of nausea and vomiting associated with motion sickness and recovery from anesthesia and surgery.
If an
anticholinergic agent reaches the CNS, the potential for cognitive impairment is a function of the extent to which the agent blocks [M.sub.1] receptors.
This bronchoconstriction was significantly reduced (% inhibition) after pretreatment with the glucocorticosteroid budesonide (49%), the [[beta].sub.2] adrenergic agent albuterol (71%), the
anticholinergic agent atropine (58%), and the histamine [H.sub.1]-antagonist diphenhydramine (47%).
But treatment with an inhaled
anticholinergic agent is still a good option for COPD patients who do not have a history of cardiovascular disease or another condition that potentially could be worsened by these drugs, commented Dr.
However, concomitant use of an intranasal corticosteroid and an intranasal
anticholinergic agent such as ipratropium bromide can be more effective for rhinorrhea than either drug alone.
Conflicting results have been found on the question of whether the bronchodilator effect of [beta] agonists is increased by adding an
anticholinergic agent, in either COPD or asthma.
(1-3) An alternative agent is the short-acting
anticholinergic agent ipratropium bromide, which is sometimes used either on its own or in combination with SABA.
Delivers 3.9 mg daily of the antispasmodic
anticholinergic agent.
Undoubtedly, if a patient with OAB is successfully managed with behavioural therapy and a single first-line
anticholinergic agent, the cost to the health care system is less than repeated treatments with BTX A.
* Overdose with an
anticholinergic agent such as an antihistamine (for example, diphenhydramine), or an ingestion of an anticholinergic plant (such as deadly nightshade or Jimson weed) or an anticholinergic mushroom.
