anticardiolipin antibody


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anticardiolipin antibody

Clinical immunology Any of a family of antibodies that recognize an epitope on the cardiolipin molecule; ACA are associated with immune-mediated disease, strokes, fetal wastage, syphilis, but are also found in healthy subjects without disease, represent natural antibodies, and indicate a normally functioning immune system Normal values IgA < 22 APL–IgA Phospholipid Units–PLU; IgG < 22 GPL–IgG PLUs; IgM < 11 MPL–IgM PLUs. See Antiphospholipid syndrome.

anticardiolipin antibody

Abbreviation: aCLa
An autoantibody against the cell membrane lipid, diphosphatidyl glycerol. It produces abnormal and sometimes life-threatening blood clotting. The antibody is found in a variety of autoimmune and infectious diseases, including in patients with the antiphospholipid antibody syndrome and syphilis.
See also: antibody

Patient discussion about anticardiolipin antibody

Q. what is anh cardiolipin antibody

A. Cardiolipin is a protein that is very common in the body. Mostly on heart and skeletal muscles. During several illnesses, mostly autoimmune, our body creates an antibody against it that do great damage and needs to cbe controlled.

More discussions about anticardiolipin antibody
References in periodicals archive ?
16] A positive test result for the anticardiolipin antibody suggests that a PMR patient is more likely to develop subsequent arteritis.
Correlation of anticardiolipin antibody igm with first trimester recurrent abortions.
Anticardiolipin antibody assay: a methodological analysis for a better consensus in routine determinations-a cooperative project of the European Anti phospholipid Forum.
It is diagnosed by the presence of antiphospholipid antibodies, such as anticardiolipin antibody or lupus anticoagulant.
At present, the only recommended investigations are testing for lupus anticoagulant and anticardiolipin antibody levels to diagnose the antiphospholipid syndrome, an acquired thrombophilia and the karyotyping of both parents for chromosomal abnormalities.
The latter include positivity (on two or more occasions, [greater than or equal to] 6 weeks apart) of either lupus anticoagulant or anticardiolipin antibody (ACA).
Anticardiolipin antibody levels were high; IgG (+): 57 GPL U/ml ( less than 12 negative), IgM (+): 120 MPL U/ ml ( less than 12 negative).