anticardiolipin antibody


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anticardiolipin antibody

Clinical immunology Any of a family of antibodies that recognize an epitope on the cardiolipin molecule; ACA are associated with immune-mediated disease, strokes, fetal wastage, syphilis, but are also found in healthy subjects without disease, represent natural antibodies, and indicate a normally functioning immune system Normal values IgA < 22 APL–IgA Phospholipid Units–PLU; IgG < 22 GPL–IgG PLUs; IgM < 11 MPL–IgM PLUs. See Antiphospholipid syndrome.

anticardiolipin antibody

Abbreviation: aCLa
An autoantibody against the cell membrane lipid, diphosphatidyl glycerol. It produces abnormal and sometimes life-threatening blood clotting. The antibody is found in a variety of autoimmune and infectious diseases, including in patients with the antiphospholipid antibody syndrome and syphilis.
See also: antibody

Patient discussion about anticardiolipin antibody

Q. what is anh cardiolipin antibody

A. Cardiolipin is a protein that is very common in the body. Mostly on heart and skeletal muscles. During several illnesses, mostly autoimmune, our body creates an antibody against it that do great damage and needs to cbe controlled.

More discussions about anticardiolipin antibody
References in periodicals archive ?
Further work-up revealed normal complement C3 and C4 tests, as well as negative antinuclear, anti-double stranded DNA, anti-Smith, and anticardiolipin antibody tests.
Levels of Anticardiolipin antibody (0% vs 100% pless than 0.0001) and lupus anticoagulant (1.5% vs 79.3% pless than 0.0001) were also significantly higher in group two.
anticardiolipin antibody (ACA), Lupus Anticoagulant (LA) were done.
The patients were persistently positive for anticardiolipin antibody or lupus anticoagulant and had a history of thromboembolism.
Antinuclear antibody, anti-nRNP antibody and anti-histone antibody were positive; however, anti-dsDNA antibody, anti-sm antibody, anticardiolipin antibody, rheumatoid factor, Coombs test (direct and indirect) and CD55CD59 were negative.
Previous reports showed also that cocaine by itself can be associated with an ANCA positive vasculitis and pseudovasculitis with special specificity for human neutrophil elastase (HNE-ANCA) in cocaine-induced midline destructive lesions, as well as anticardiolipin antibody production [16-18].
(4) Auto-antibodies: antinuclear antibody (ANA), anti-Sm antibody, anti-dsDNA antibody, anticardiolipin antibody (ACL), and anti-[beta]2-glycoprotein-1 antibody (anti-[beta]2-GP-1).
These studies were of small populations, however, and did not follow the current strict guidelines for classifying anticardiolipin antibody and lupus anticoagulant concentrations as positive (27).
Yes, warfarin is effective in the secondary prevention of venous thromboembolic events (VTEs) for patients positive for lupus anticoagulant or anticardiolipin antibody (also known as antiphospholipid antibodies [aPL]) (strength of recommendation [SOR]: B, single cohort study, extrapolation from other RCTs).
Correlation of anticardiolipin antibody igm with first trimester recurrent abortions.
Distinguishing beta2-glycoprotein I dependent (systemic lupus erythematosus type) and independent (syphilis type) anticardiolipin antibody with Tween-20.
Currently, the only recommended investigations are testing for lupus anticoagulant and anticardiolipin antibody levels.