SAN DIEGO -- While use of the investigational agent blisibimod did not meet the primary endpoint in a phase 3 trial in systemic lupus erythematosus (SLE), it was associated with steroid sparing, decreased urine protein, a trend toward decreased anti-double-stranded DNA antibodies, and significant decreases in
anticardiolipin antibodies and immunoglobulin levels.
Lucio Leprosy with Lucio's phenomenon, digital gangrene and
anticardiolipin antibodies.
More specific immunological studies can be performed to confirm the diagnosis including
Anticardiolipin antibodies test.
Moreover, no difference was detected in terms of
anticardiolipin antibodies, lupus anticoagulant, and APS (Table 2).
4,5] Premature ischaemic heart disease may occur as in our patient; however, the role of
anticardiolipin antibodies in this condition is not clear.
Detection of 'antiphospholipid' antibodies: a single chromogenic assay of thrombin generation sensitively detects lupus anticoagulants,
anticardiolipin antibodies, plus antibodies binding [[beta].
In Group-I,
anticardiolipin antibodies (aCL) were most common (86%).
The following radiographic and laboratory studies were normal: CT angiography of the brain, electroencephalogram, paraneoplastic antibodies, screening for coagulation disorders including platelet count, fibrinogen, prothrombin time, activated partial thromboplastin time, international normalized ratio, platelet aggregation and
anticardiolipin antibodies.
Anti-double stranded DNA, antineutrophil cytoplasmic antibodies,
anticardiolipin antibodies, C-reactive protein, complete blood count, and urinalysis were all normal or negative.
The three pregnancies with fetal loss included two women who tested positive for
anticardiolipin antibodies.
Laboratory findings revealed anemia, leukopenia, Coombs' positivity, hypergamaglobulinemia and positive
anticardiolipin antibodies but blood cultures were negative.
They are often concurrent with
anticardiolipin antibodies and both cause antiphospholipid syndrome (APS).
