SAN DIEGO -- While use of the investigational agent blisibimod did not meet the primary endpoint in a phase 3 trial in systemic lupus erythematosus (SLE), it was associated with steroid sparing, decreased urine protein, a trend toward decreased anti-double-stranded DNA antibodies, and significant decreases in anticardiolipin antibodies
and immunoglobulin levels.
Lucio Leprosy with Lucio's phenomenon, digital gangrene and anticardiolipin antibodies
More specific immunological studies can be performed to confirm the diagnosis including Anticardiolipin antibodies
Moreover, no difference was detected in terms of anticardiolipin antibodies
, lupus anticoagulant, and APS (Table 2).
4,5] Premature ischaemic heart disease may occur as in our patient; however, the role of anticardiolipin antibodies
in this condition is not clear.
Detection of 'antiphospholipid' antibodies: a single chromogenic assay of thrombin generation sensitively detects lupus anticoagulants, anticardiolipin antibodies
, plus antibodies binding [[beta].
In Group-I, anticardiolipin antibodies
(aCL) were most common (86%).
The following radiographic and laboratory studies were normal: CT angiography of the brain, electroencephalogram, paraneoplastic antibodies, screening for coagulation disorders including platelet count, fibrinogen, prothrombin time, activated partial thromboplastin time, international normalized ratio, platelet aggregation and anticardiolipin antibodies
Anti-double stranded DNA, antineutrophil cytoplasmic antibodies, anticardiolipin antibodies
, C-reactive protein, complete blood count, and urinalysis were all normal or negative.
The three pregnancies with fetal loss included two women who tested positive for anticardiolipin antibodies
Laboratory findings revealed anemia, leukopenia, Coombs' positivity, hypergamaglobulinemia and positive anticardiolipin antibodies
but blood cultures were negative.
They are often concurrent with anticardiolipin antibodies
and both cause antiphospholipid syndrome (APS).