antibody-dependent cell-mediated cytotoxicity


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Related to antibody-dependent cell-mediated cytotoxicity: antibody-dependent cell-mediated cytotoxicity (ADCC)

cytotoxicity

 [si″to-tok-sis´ĭ-te]
1. the degree to which an agent has specific destructive action on certain cells.
2. the possession of such destructive action, particularly in reference to lysis of cells by immune phenomena and to antineoplastic agents that selectively kill dividing cells. adj., adj cytotox´ic.
antibody-dependent cell-mediated cytotoxicity (ADCC) (antibody-dependent cellular cytotoxicity) lysis of target cells coated with antibody by effector cells with cytolytic activity and specific immunoglobulin receptors called Fc receptors, including K cells, macrophages, and granulocytes. Lysis of the target cell is extracellular, requires direct cell-to-cell contact, and does not involve complement.
cell-mediated cytotoxicity destruction of a target cell by specific lymphocytes, such as cytotoxic T lymphocytes or NK cells; it may be antibody-dependent (see antibody-dependent cell-mediated c.) or independent, as in certain cell-mediated hypersensitivity reactions.

an·ti·bo·dy-de·pen·dent cell-·me·di·at·ed cy·to·tox·i·ci·ty (ADCC),

a form of cell-mediated cytotoxicity mediated by natural killer cells with membrane bound Fc receptors. NK cells bind to antibody-coated microbes and the target cell may be killed through various modalities, for example, perforin, reactive oxygen intermediates, cytokines.

antibody-dependent cell-mediated cytotoxicity

The killing of a target cell, which has been coated with an antibody, by a MACROPHAGE, neutrophil or natural killer cell that carries the surface receptor that binds to the particular antibody.
References in periodicals archive ?
Kennedy, "Immunization of BALB/c mice with recombinant simian virus 40 large tumor antigen induces antibody-dependent cell-mediated cytotoxicity against simian virus 40-transformed cells: an antibody-based mechanism for tumor immunity," Journal of Immunology, vol.
Darzalex is believed to induce tumor cell death through multiple immune-mediated mechanisms of action, including complement-dependent cytotoxicity, antibody-dependent cell-mediated cytotoxicity and antibody-dependent cellular phagocytosis, as well as through apoptosis, in which a series of molecular steps in a cell lead to its death.
ALT-803 also potently activates NK cells and enhances antibody-dependent cell-mediated cytotoxicity of antibodies in various experimental models.
It has been designed to have significantly improved antibody-dependent cell-mediated cytotoxicity (ADCC), therefore enhancing a central mechanism for tumour cell killing and potentially providing increased efficacy than traditional anti-cancer antibodies.
Merus will use the GlymaxX platform to improve the ADCC (Antibody-Dependent Cell-Mediated Cytotoxicity) activity of one of its lead therapeutics, namely a bispecific anti-cancer antibody for the treatment of solid tumours.

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