In addition to MTX, antiarthritic
effects elicited through FR[beta] targeting have been reported for folate-conjugated immunotoxins  and various folate-conjugated drugs [30, 41, 42].
Wei et al., "Oral curcumin has antiarthritic
efficacy through somatostatin generation via cAMP/PKA and [Ca.sup.2+]/CaMKII signaling pathways in the small intestine," Pharmacological Research, vol.
Hei-Gu-Teng Zhuifenghuoluo granule (HGT) was an antiarthritic
Chinese herbal formula in China , which is identified as the over-the-counter (OTC) drug for treatment of arthritis by the Chinese State Food and Drug Administration (CFDA), composed of Periploca forrestii Schltr., Sinomenium acutum (Thunb.) Rehd et Wils., and Lysimachia paridiformis Franch.
Son et al., "Antiarthritic
effect of bee venom: Inhibition of inflammation mediator generation by suppression of NF-?B through interaction with the p50 subunit," Arthritis, vol.
The species has been explored for various biological life supporting properties like, antibiotic, antifertility, wound healing , immunomodulatory , anthelmintic , antinociceptive, antitumor , antipyretic, larvicidal, insecticidal, pesticidal , antiulcer, antiarthritic
, antidiarrheal , antidiabetic , neuropharmacological, antioxidant, and anticancer activities .
Similarly, the compounds [alpha] and [beta]-Amyrin present in hexane and methanol extracts are known to possess antidiabetic, anti-inflammatory, antiarthritic
, and anticancer activities .
This aromatic phytochemical has anti-inflammatory, analgesic, antiarthritic
, antiallergic, anticarcinogenic, antidiabetic, cardioprotective, gastroprotective, hepatoprotective, and neuroprotective properties .
Plants like Calotropis, cinnamon, garlic and true myrtle are used as antiarthritic
and antirheumatic agents.
 demonstrated that immunomodulatory and antiarthritic
potential of patuletin was associated with inhibited production of the proinflammatory cytokine TNF-[alpha] with no cytotoxic property.
Both garlic and onion have been shown to have applications as antimicrobial, antithrombotic, antitumor, hypolipidaemic, antiarthritic
and hypoglycemic agents.
Another important constituent of mango (also found in olive, strawberry, fig, and various medicinal herbs) is the triterpene lupeol, which has been characterized as exhibiting potent antioxidant, antimutagenic, anti-inflammatory, and antiarthritic
activity (Oncogene 2004;23:5203-14).