antiangiogenesis

antiangiogenesis

Oncology Prevention of the growth of new blood vessels into a solid tumor. See angiogenesis.

antiangiogenesis

(ant?e-an?je-o-jen'e-sis) [ anti- + angiogenesis]
Prevention of the formation of new blood vessels, esp. the blood vessels that grow under the influence of malignant tumors. Agents causing antiangiogenesis include angiostatin, endostatin, tetracyclines, and paclitaxel. They are useful in the treatment of cancer. See: angiogenesis
References in periodicals archive ?
Antiangiogenesis effect of essential oil from Curcuma zedoaria in vitro and in vivo.
Antiangiogenesis mediates cisplatin-induced peripheral neuropathy: attenuation or reversal by local vascular endothelial growth factor gene therapy without augmenting tumor growth.
Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy.
A research showed that IMiDs exhibited antiangiogenic effects on lymphoma in mice.[9] With the upregulation of SPARC, a tumor-suppressor gene that displays antiproliferative, antiadhesive, and antiangiogenic properties in 5q- syndrome, lenalidomide was considered antiangiogenesis in vivo .[10] In 2009, Dredge et al .[11] revealed that lenalidomide inhibited the phosphorylation of vascular endothelial growth factor-induced Akt-1 in endothelial cells and offered more solid proof for this mechanism.
(7) Antiangiogenesis therapy has, thus, emerged as a new therapeutic opportunity for the treatment of cancer.
2-methoxyestradiol is an antiangiogenesis agent which inhibits the growth of cancer cells such as leukemia, multiple myeloma, cervical, hepatocellular, colorectal, gastric, angiosarcoma, pancreatic and neuroblastoma [1-4].
Adiponectin-induced antiangiogenesis and antitumor activity involve caspase mediated endothelial cell apoptosis.
The function of apatinib, as a small molecular tyrosine kinase targeting VEGF-R2 (vascular endothelial growth factor receptor-2), is antiangiogenesis. There is another case report of targeted therapy with apatinib in a patient with advanced gastric cancer and high serum level of AFP and PFS achieved five months [31].
Silver nanoparticles specifically have gained attention due to their unusual physiochemical [2] (chemical stability and electrical conductivity) and biological activities such as antibacterial, antifungal, anti-inflammatory, antiviral, antiangiogenesis, anticancer, and antiplatelet activities [3-5].
Taken together, [sup.18]F-Alfatide II PET/CT may not only detect chronic inflammation but also allow the evaluation of angiogenesis and neovascularization during chronic inflammation and guide the selection of patients for antiangiogenesis therapy.
Recent accumulating evidence shows that several species of the Rheum genus such as Rheum emodi, Rheum undulatum L., Rhizoma Rhei, Rheum ribes, Rheum palmatum L., and Rheum rhaponticum have antiallergic, antibacterial, antioxidant, anticancer, antiangiogenesis, and anti-inflammation properties [11-20].
Future directions in management of metastatic melanoma include vaccine, antiangiogenesis, and targeted therapies against NRAS, RAC1, ERK, and PI3K and c-KIT or PTEN.