Lopaschuk, "The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase," Circulation Research, vol.
Previous clinic studies have demonstrated that CDDP is safe and effective in the treatment of CHD; its antianginal effect is even more effective than isosorbide dinitrate [38].
Assessment of antianginal and antiischemic effect of trimetazidine and its effects on myocardial perfusion in patients with ischemic heart disease and stable angina.
A post hoc analysis from that trial suggested that ranolazine, a late sodium current inhibitor, also had potential as a glucose-lowering agent-something not seen with other antianginal drugs, said Dr.
Any patient having compromised cardio-pulmonary or renal status or on any medications like beta blocker, antihypertensive, antianginal drugs, anxiolytics or analgesics, obese patient (wt more than 80 kg), or patient hypersensitive to any drug used in the study, were excluded from the study.
(42) And in a six-month study of patients with known ischemic heart disease (poor blood circulation to heart muscle), magnesium supplementation led to an impressive decrease in angina attacks and a decrease in the use of antianginal drugs such as nitroglycerin.
For example, in cardiovascular diseases, as frequencies of occurrence of myocardial infarction and cardiac arrest are more common from morning to noon, optimal antihypertensive and/or antianginal drug is to be delivered in morning time [8].