antiandrogen

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androgen

 [an´dro-jen]
any steroid hormone that promotes male secondary sex characters. The two main androgens are androsterone and testosterone. Called also androgenic hormone. adj., adj androgen´ic. 

The androgenic hormones are internal endocrine secretions circulating in the bloodstream and manufactured mainly by the testes under stimulation from the pituitary gland. To a lesser extent, androgens are produced by the adrenal glands in both sexes, as well as by the ovaries in women. Thus women normally have a small percentage of male hormones, in the same way that men's bodies contain some female sex hormones, the estrogens. Male secondary sex characters include growth of the beard and deepening of the voice at puberty. Androgens also stimulate the growth of muscle and bones throughout the body and thus account in part for the greater strength and size of men as compared to women.
androgen insensitivity syndrome complete androgen resistance.

an·ti·an·dro·gen

(an'tē-an'drō-jen),
Any substance capable of preventing full expression of the biologic effects of androgenic hormones on responsive tissues, either by producing antagonistic effects on the target tissue, as estrogens do, or by merely inhibiting androgenic effects, such as by competing for binding sites at the cell surface.

antiandrogen

/an·ti·an·dro·gen/ (-an´dro-jen) any substance capable of inhibiting the biological effects of androgens.

antiandrogen

(ăn′tē-ăn′drə-jən, ăn′tī-)
n.
A substance that inhibits the biological effects of androgenic hormones.

antiandrogen

Endocrinology A hormone or other agent–eg, megestrol acetate, spironolactone, flutamide, nilutamide, and cimetidine, which interferes with androgen function by competitively inhibiting androgen binding to cognate receptors at the target organ and is either biologically inert or functionally very weak; these compounds are used to manage androgen-dependent CAs–♂ breast and prostate, hirsutism, acne

Antiandrogen

A substance that blocks the action of androgens, the hormones responsible for male characteristics. Used to treat prostate cancers that require male hormones for growth.
Mentioned in: Prostate Cancer

antiandrogen

any substance capable of inhibiting the biological effects of androgenic hormones.
References in periodicals archive ?
Further, BPS and BPF have potencies in the same order of magnitude as BPA in regard to androgenic, antiandrogenic, antiestrogenic, and aryl hydrocarbon activity and inhibitory hormonal signaling in adipocytes (Table 4).
In addition, DiNP is an analog of DEHP--the reason for replacing DEHP with DiNP in soft PVC is that the two molecules have common chemical properties, which may also include antiandrogenic action.
We divided estimated DIs by their corresponding TDI to derive HQs for phthalate diesters with evidence of antiandrogenic effects--DiBP, DnBP, BBzP, and DEHP--and combined the HQ estimates for these compounds to derive a single estimated hazard index (HI) for each infant (Koch et al.
However, the pattern of associations observed with reproductive hormones in the present study suggests the possibility that at environmental BPA exposure levels an antiestrogenic or antiandrogenic effect, or both, of BPA on the hypothalamic-pituitary-gonadal hormone feedback system may be a potential mode of action, possibly through a competitive inhibition on the receptor level.
A slight antiandrogenic effect of phenanthrene was similarly reported by Vinggaard et al.
One explanation for the consistent LMW association across this study and the other two human studies is that MBP, an LMW metabolite with potential antiandrogenic effects, is metabolized readily to MEP (Committee on the Health Risks of Phthalates-National Research Council 2008).
In utero MEHP exposure causes antiandrogenic effects in the rat fetal testis, demonstrating that this critical window of development is sensitive to toxic insult.
Inasmuch as large populations are regularly exposed to mixtures of antiandrogenic pesticides, our results underline the need for considering combination effects for these substances in regulatory practice.
1995), but in vivo, phthalates have mostly shown antiandrogenic effects through inhibition of testosterone synthesis (Gray et al.
2008) reported antiandrogenic effects, such as hypospadias and reduced AGD, in mice exposed gestationally to phthalates.
One potential mechanism for p,p'-DDE affecting mammary carcinogenesis is through its antiandrogenic actions.
Many phthalates are identified as antiandrogenic EDCs in mammalian models, whereas DEP is not generally characterized as an endocrine-active compound (Hannas et al.