antiandrogen

(redirected from antiandrogenic)
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androgen

 [an´dro-jen]
any steroid hormone that promotes male secondary sex characters. The two main androgens are androsterone and testosterone. Called also androgenic hormone. adj., adj androgen´ic. 

The androgenic hormones are internal endocrine secretions circulating in the bloodstream and manufactured mainly by the testes under stimulation from the pituitary gland. To a lesser extent, androgens are produced by the adrenal glands in both sexes, as well as by the ovaries in women. Thus women normally have a small percentage of male hormones, in the same way that men's bodies contain some female sex hormones, the estrogens. Male secondary sex characters include growth of the beard and deepening of the voice at puberty. Androgens also stimulate the growth of muscle and bones throughout the body and thus account in part for the greater strength and size of men as compared to women.
androgen insensitivity syndrome complete androgen resistance.

an·ti·an·dro·gen

(an'tē-an'drō-jen),
Any substance capable of preventing full expression of the biologic effects of androgenic hormones on responsive tissues, either by producing antagonistic effects on the target tissue, as estrogens do, or by merely inhibiting androgenic effects, such as by competing for binding sites at the cell surface.

antiandrogen

(ăn′tē-ăn′drə-jən, ăn′tī-)
n.
A substance that inhibits the biological effects of androgenic hormones.

antiandrogen

Endocrinology A hormone or other agent–eg, megestrol acetate, spironolactone, flutamide, nilutamide, and cimetidine, which interferes with androgen function by competitively inhibiting androgen binding to cognate receptors at the target organ and is either biologically inert or functionally very weak; these compounds are used to manage androgen-dependent CAs–♂ breast and prostate, hirsutism, acne

Antiandrogen

A substance that blocks the action of androgens, the hormones responsible for male characteristics. Used to treat prostate cancers that require male hormones for growth.
Mentioned in: Prostate Cancer
References in periodicals archive ?
Administration of potentially antiandrogenic pesticides (procymidone, linuron, iprodione, chlozolinate, p, p'-DDE, and ketoconazole and toxic substance (dibutyland diethylhexyl phthalate, PCB 169, and ethane dimethane sulphonate) during sexual differentiation produces diverse profiles of reproductive malformations in the male rat.
See also Karen Harrison, Legal and Ethical issues when using Antiandrogenic Pharmacotherapy with Sex Offenders, 3 SEXUAL OFFENDER TREATMENT, 2008, http://www.sexualoffender-treatment.org/ 2-2008_01.html (citing antiandrogen use in California and Montana as mandated by legislature); Kris W.
africana can be divided into three major categories based on their targets and pharmacological effects (Table 1): (i) phytochemicals that kill the tumor cells through apoptotic pathways, a common mode of action of chemotherapeutic agents against a wide variety of cancer cells [60], (ii) phytochemicals that alter the signaling pathways required for the maintenance of prostate cancer cells, and (iii) phytochemicals that exhibit strong antiandrogenic and antiangiogenic activities.
Besides, molecular docking was employed to investigate the possible interaction mechanisms of the samples owning high in silico antiandrogenic activities with AR.
Drospirenone (DRP), another steroidal progestin, has antiandrogenic and antimineralocorticoid activities which other progestins lack.[sup][21] Combined with 30-[micro]g ethinyl estradiol (EE), it has previously been used as DRP/EE COCs in the treatment of PCOS.[sup][22],[23],[24],[25] In recent years, studies have showed that the DRP-containing COCs had no negative metabolic effects on women with PCOS, and some studies reported favorable metabolic effects.[sup][21],[23],[24],[25],[26] However, few studies have investigated the combination of DRP-containing COCs and metformin,[sup][27],[28] and the effects of DRP-containing COCs on carbohydrate and lipid metabolism in women with PCOS and dysfunctional metabolism have not, to date, been investigated.
With combination of MI and OCPs antiandrogenic activity was extremely marked and was expressed by significant reduction in TT, FT, DHEA-S, FAI, and LH.
DISCUSSION: Mifepristone is a PROGESTERONE RECEPTOR MODULATOR with antiprogestogenic, antiglucocorticoid and weak antiandrogenic activity.
Kelce, The estrogenic and antiandrogenic pesticide methoxychlor alters the reproductive tract and behaviour without affecting pituitary size or LH and prolactin secretion in male rats", Toxicology and Industrial Health, 15, 37e47, (1999a)
1997).Exposure of pesticides exhibited pathological changes in testicular tissues and this alteration occurred as antiandrogenic effects (Garry et al 2001; Lu et al.2004 and Dallegrave at al.
(19) Studies of cell cultures, laboratory animals, and accidentally exposed humans do show that chemicals can produce estrogenic, androgenic, antiandrogenic, and antithyroid actions in the body.
The other linoleic acid ester, 9-octadecenoic acid (Z)-, methyl ester, is also having anti-inflammatory, antiandrogenic, and anemiagenic properties [32].
Thiohydantoins [11, 12] are potential bioactive heterocyclic compounds with pharmaceutical and agricultural applications [13] due to their antimicrobial [14], antiviral [15], anti-inflammatory [13], antitumor [16, 17], and antiandrogenic properties [18].