antiandrogen


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androgen

 [an´dro-jen]
any steroid hormone that promotes male secondary sex characters. The two main androgens are androsterone and testosterone. Called also androgenic hormone. adj., adj androgen´ic. 

The androgenic hormones are internal endocrine secretions circulating in the bloodstream and manufactured mainly by the testes under stimulation from the pituitary gland. To a lesser extent, androgens are produced by the adrenal glands in both sexes, as well as by the ovaries in women. Thus women normally have a small percentage of male hormones, in the same way that men's bodies contain some female sex hormones, the estrogens. Male secondary sex characters include growth of the beard and deepening of the voice at puberty. Androgens also stimulate the growth of muscle and bones throughout the body and thus account in part for the greater strength and size of men as compared to women.
androgen insensitivity syndrome complete androgen resistance.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

an·ti·an·dro·gen

(an'tē-an'drō-jen),
Any substance capable of preventing full expression of the biologic effects of androgenic hormones on responsive tissues, either by producing antagonistic effects on the target tissue, as estrogens do, or by merely inhibiting androgenic effects, such as by competing for binding sites at the cell surface.
Farlex Partner Medical Dictionary © Farlex 2012

antiandrogen

(ăn′tē-ăn′drə-jən, ăn′tī-)
n.
A substance that inhibits the biological effects of androgenic hormones.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

antiandrogen

Endocrinology A hormone or other agent–eg, megestrol acetate, spironolactone, flutamide, nilutamide, and cimetidine, which interferes with androgen function by competitively inhibiting androgen binding to cognate receptors at the target organ and is either biologically inert or functionally very weak; these compounds are used to manage androgen-dependent CAs–♂ breast and prostate, hirsutism, acne
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

Antiandrogen

A substance that blocks the action of androgens, the hormones responsible for male characteristics. Used to treat prostate cancers that require male hormones for growth.
Mentioned in: Prostate Cancer
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
For example, 20 of the 50 pesticides with the highest exposure scores were antiandrogenic in at least one assay, including 8 that have not been identified as antiandrogens previously [see Supplemental Material, Figure 2 (doi:10.1289/ ehp.
KEY WORDS: antiandrogens, azole fungicides, combination effects, cumulative effects, DEHP, dose addition, finasteride, independent action, male sexual differentiation, mixtures, phthalates, prochloraz, vinclozolin.
By the same token, any antiandrogen effects during this period of human development may be reflected in decrements in AGD measurements.
The results of the Hershberger bioassay with these test substances have been compared with results of androgen and antiandrogen study outcomes from developmental and reproductive assays (Table 6).
Kovacs, who was not involved in the new study, recommended that before prescribing medication to patients who take antiandrogen drugs, doctors check CredibleMeds.org.
Here, we characterize for the first time the longitudinal outcome of circulating fetuin-A concentrations in nonobese adolescents with PCOS and show that fetuin-A levels normalize after treatment with a low-dose combination of insulin sensitizers and an antiandrogen, but not after OC.
Those who had acute urinary retention, conversion to prostatic surgery, conversion to another [alpha]1-adrenoceptor antagonist, add-on of antiandrogen or 5[alpha]-reductase inhibitors, and discontinuation of silodosin treatment for lack of efficacy were defined as the treatment-failure group.
The studied molecular structures and corresponding antiandrogen activities were listed in Table 1.
Spironolactone also has antiandrogen properties, and while it is not Food and Drug Administration-approved for the treatment of acne, the AAD guidelines support selective use in women.
Exclusion criteria were patients who received topical therapy (monoxidl, corticosteroids) and systemic drugs (steroids, finasteride or antiandrogen) during last six months and any other active disease at the site of intended treatment.