antiandrogen


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androgen

 [an´dro-jen]
any steroid hormone that promotes male secondary sex characters. The two main androgens are androsterone and testosterone. Called also androgenic hormone. adj., adj androgen´ic. 

The androgenic hormones are internal endocrine secretions circulating in the bloodstream and manufactured mainly by the testes under stimulation from the pituitary gland. To a lesser extent, androgens are produced by the adrenal glands in both sexes, as well as by the ovaries in women. Thus women normally have a small percentage of male hormones, in the same way that men's bodies contain some female sex hormones, the estrogens. Male secondary sex characters include growth of the beard and deepening of the voice at puberty. Androgens also stimulate the growth of muscle and bones throughout the body and thus account in part for the greater strength and size of men as compared to women.
androgen insensitivity syndrome complete androgen resistance.

an·ti·an·dro·gen

(an'tē-an'drō-jen),
Any substance capable of preventing full expression of the biologic effects of androgenic hormones on responsive tissues, either by producing antagonistic effects on the target tissue, as estrogens do, or by merely inhibiting androgenic effects, such as by competing for binding sites at the cell surface.

antiandrogen

/an·ti·an·dro·gen/ (-an´dro-jen) any substance capable of inhibiting the biological effects of androgens.

antiandrogen

(ăn′tē-ăn′drə-jən, ăn′tī-)
n.
A substance that inhibits the biological effects of androgenic hormones.

antiandrogen

Endocrinology A hormone or other agent–eg, megestrol acetate, spironolactone, flutamide, nilutamide, and cimetidine, which interferes with androgen function by competitively inhibiting androgen binding to cognate receptors at the target organ and is either biologically inert or functionally very weak; these compounds are used to manage androgen-dependent CAs–♂ breast and prostate, hirsutism, acne

Antiandrogen

A substance that blocks the action of androgens, the hormones responsible for male characteristics. Used to treat prostate cancers that require male hormones for growth.
Mentioned in: Prostate Cancer

antiandrogen

any substance capable of inhibiting the biological effects of androgenic hormones.
References in periodicals archive ?
Use of antiandrogens can produce reduction in lean muscle mass while causing increase in fat mass due to increased insulin resistance as observed in patients of prostate cancer receiving antiandrogens9-10.
This mutation occurs in the ligand-binding domain, and results in decreased ligand specificity, whereby other hormones such as progesterone, estrogens, and many antiandrogens can also activate the protein.
Table 3 Monitoring patients receiving antiandrogen medications Pre-therapy workup Periodic monitoring Endocrinology or Monthly: testosterone for the first 6 months internist consultation Bone scan Every 6 months: testosterone, LH, FSH, prolactin, CBC, renal function, liver function, fasting glucose and lipids, weight, blood pressure Weight Yearly: bone scan Blood pressure Electrocardiogram CBC, renal function, liver function, fasting glucose, and lipids LH, FSH, testosterone, prolactin CBC: complete blood count; FSH: follicle-stimulating hormone; LH: Iuteinizing hormone Source: References 19, 27, 31
One of the methods utilized to study the effect of testosterone in their target cells, is the administration of antiandrogens like flutamide, a non esteroidal molecule, In the organisms, this molecule is metabolized to 2-hidroxyflutamide and it blocks the receptors competitively with effects similar to those provoked by nilutamida (Brodgen & Clissold, 1989).
COCs can be used alone or along with antiandrogens and insulin sensitizing agents to improve control of unwanted body hair.
Cooper, "A Placebo-controlled Trial of the Antiandrogen Cyproterone Acetate in Deviant Hypersexuality," Comprehensive Psychiatry, vol.
Conversely, the antiandrogen Nilandron[R] has consistently shown a survival benefit in orchiectomy patients (Bertagna et al.
Treatment of male hypersexual conditions by a non-oestrogenic antiandrogen.
Finally, the doctor may prescribe an antiandrogen drug, such as spironolactone, which helps prevent androgens from causing excessive oil production.
Sometimes antiandrogen therapy is used in conjunction with LHRH therapy.
Although bicalutamide was discontinued due to watching antiandrogen withdrawal syndrome, the serum PSA level increased even more.
However, DiNP is less potent as an antiandrogen than the other phthalates.