Members of the phenanthroindolizidine alkaloid class are known to exhibit pronounced cytotoxicity and
antiamebic, antifungal, antibacterial, and anti-inflammatory activities and to also inhibit enzymes involved in the synthesis of DNA and proteins, and several alkaloids and their N-oxides (32-35) were obtained from the extract of F.
Retrospectively, the ineffectiveness of antibiotics and
antiamebic drugs suggested an unusual infection.
In that case an early diagnosis of PAM was made via an astute technician's visualization of ameba on a wet-mount of CSF, and aggressive
antiamebic therapy was started promptly.
Oral immunization with attenuated vaccine strains of Vibrio cholerae expressing a dodecapeptide repeat of the serine-rich Entamoeba histolytica protein fused to the cholera toxin B subunit induces systemic and mucosal
antiamebic and anti-V.
Oral immunization with an attenuated vaccine strain of Salmonella typhimurium expressing the serine-rich Entameba histolytica protein induces an
antiamebic immune response and protects gerbils from amebic liver abscess.
histolytica and be treated unnecessarily with
antiamebic chemotherapy.
Many cases were misdiagnosed as amebiasis, and treatment with
antiamebic drugs contributed to the high mortality (2,3).
