Positive antitissue transglutaminase (anti-TTG
) titers were identified in all diagnosed FDRs.
PerkinElmer's EUROIMMUN anti-tTG
ELISA helps clinical laboratories screen patients more accurately by determining and quantifying immunoglobulin class A (IgA) and class G (IgG) anti-tTG
Parents visited a hospital in Lahore and got diagnosis of coeliac disease on the basis of increased anti-tissue transglutaminase-antibodies (anti-TTG
) antibodies at the age of one and half year.
In the 16 included studies, anti-tTG
was used in 12 studies (anti-tTG
alone in 5 studies; with EMA in 3; with AGA in one; with EMA and AGA in 2; with EMA and AGA and ARA in one), and biopsy was used in 14 studies.
The one patient with celiac disease had high levels of anti-tTG
IgA antibodies (36 U/mL) while most of the others had an approximate level of 2 U/mL.
Similarly, autoantibodies targeting tissue transglutaminase (anti-TTG
) have been significantly associated with a higher risk of hip fracture and reduced BMD levels in celiac disease [18,19].
(10) Almost all patients with dermatitis herpetiformis will have positive serologic testing for anti-tissue transglutaminase (anti-tTG
All of the patients had anti-tTG
IgA antibody titres.
The following laboratory tests were performed: ASCA (anti-Saccharomyces cerevisiae antibodies) IgG/IgA, 6 antigens associated with ANCA (anti-neutrophil cytoplasm antibodies), anti-tTG
(anti-transglutaminase) IgG/IgA, anti-DGP (anti-deamidated gliadin peptide antibodies) IgG/IgA, ANAs (antinuclear antibodies), and total IgA.
Anti-CK18 antibody (Cell Signaling), anti-tTG
(Cell Signaling) antibody, anti-[alpha]-enolase antibody (Santa Cruz), and anti-actin antibody (Santa Cruz) were used.
Repeat investigations including anti-tTG
antibody were normal.