anti-neutrophilic cytoplasmic antibodies
anti-neutrophilic cytoplasmic antibodiesOne of two (or three, if including x-ANCA) different IgG antibodies seen in patients with autoimmune diseases and ANCA-related vasculidites.
▪ c-ANCA (Cytoplasmic) (classic)—Autoantibodies against proteinase 3; diffuse cytoplasmic staining; seen in Wegener’s granulomatosis.
▪ p-ANCA (Protoplasmic)—Autoantibodies against myeoperoxidase; perinuclear staining; seen in ulcerative colitis, Churg-Strauss syndrome, primary sclerosing cholangitis, polyarteritis nodosa (microscopic polyangiitis variant), focal necrotising and crescentic glomerulonephritis, rheumatoid arthritis.
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