anti-mitochondrial antibody


Also found in: Acronyms, Wikipedia.

anti-mitochondrial antibody

Any antibody that reacts to various mitochondrial antigens; one such antigen is M2, which evokes the production of an AMA present in 90-95% of Pts with PBC, some of whom also have scleroderma; AMA is directed against the ATPase lipoprotein present on the inner mitochondrial membrane
References in periodicals archive ?
While anti-nuclear antibody levels were negative, the anti-mitochondrial antibody level was elevated at 26.5 units (<20 units).
(11) While anti-nuclear antibody (ANA) is only positive in approximately 70% of patients with PBC12, anti-mitochondrial antibody (AMA) is found in nearly 95% of cases.
Anti-mitochondrial antibody (AMA) positivity is the serologic hallmark of PBC.
Abbreviations PBC: Primary biliary cirrhosis SNP: Single nucleotide polymorphism GWAS: Genome-wide association study IL12: Interleukin12 STAT4: Signal transducer and activator of transcription 4 AMA: Anti-mitochondrial antibody ANA: Anti-nuclear antibody PBMCs: Peripheral blood mononuclear cells LD: Linkage disequilibrium Pc: Corrected P OR: Odds ratio CI: Confidence interval.
PBC is most likely an autoimmune disorder (2), and anti-mitochondrial antibody (anti-M2) has been a diagnostically very useful marker: several studies have reported a positivity rate for anti-M2 of >95% in biopsy-confirmed PBC patients (3).

Full browser ?