anti-idiotype

anti-idiotype

an ANTIBODY that can recognize and bind to the antigen binding site of another antibody. See IDIOTYPE.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005
References in periodicals archive ?
The development of new vaccines, such as subunit vaccines, synthetic vaccines, recombinant vaccines and anti-idiotype vaccines, which combine efficacy, innocuity, duration of protection, ease of use, stability and multivalence.
Inhibition of autoimmune tubulointerstitial nephritis in guinea pigs by heterologous antisera containing anti-idiotype antibodies.
Fuller, "Identification by anti-idiotype antibodies of an intracellular membrane protein that recognizes a mammalian endoplasmic reticulum retention signal," Nature, vol.
Presence of tolerance generating anti-idiotype antibodies to mast cell degranulating antigens that induce remission of the disease forms the basis of AST and this therapy has been tried in various autoimmune diseases.6
Both P3 and its anti-idiotype 1E10 have [V.sub.H] chains encoded by germline genes and the P3 [V.sub.H], Q52, is highly represented in the fetal B-1a cell repertoire.
Basis of this treatment is Autologous serum containing tolerancegenerating anti-idiotype antibodies to mast cell degranulating antigens.
Other methodologies for smaller haptens include idiometric assay with anti-idiotype antibodies (15-17), antimetatype antibody--based immunoassay (18, 19), and open sandwich immunoassay (20, 21).
(2008) The role of anti-idiotype antibodies to alpha-fetoprotein in oncogenesis.
Furthermore, irrelevant isotype-matching antibody (an anti-idiotype mAb, clone 2F9-G5 (IgGl/[kappa])) was included in the experiments.
Several clinical trials have been performed with the anti-NeuGc-containing gangliosides anti-idiotype monoclonal antibody racotumomab (also known as 1E10) and the conjugated NeuGcGM3/VSSP (very small size proteoliposomes) nanoparticle vaccine for immunotherapy of melanoma, breast, and lung cancer.
Clarke (24) proposed that cross-reactivity with microbial antigens could induce interferon-gamma production and possiblely generate anti-idiotype antibodies.