anti-double-stranded DNA antibody

(redirected from anti-ds-DNA antibody)

anti-double-stranded DNA antibody

An autoantibody against DNA, which is often present in systemic lupus erythematosus (SLE), measured in patients known to have antinuclear antibodies associated with lupus (glomerulo) nephritis, a major complication of SLE. Anti-ds DNA antibody testing is more specific than subjective interpretation of fluorescent staining patterns.
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References in periodicals archive ?
Anti-nuclear antibody (ANA), Anti-Ds-DNA antibody was positive and anticardiolipin IgG antibodies were negative, C-reactive protein (CRP) =3.95 mg/L, C3 was decreased and C4 was normal.
Anti-ds-DNA antibody showed an increase to 90IU/mL (normal: <12).
Detection of anti-ds-DNA antibody (ds-DNA-Ab) is an integral part of the definition of systemic lupus erythematosus (SLE) as proposed by the American College of Rheumatology (ACR) criteria (3).