anti-angiogenic drugs

anti-angiogenic drugs

A group of currently experimental anticancer drugs that act by inhibiting the growth of the small blood vessels on which cancers depend for their growth. The group includes ANGIOSTATIN, ENDOSTATIN, THALIDOMIDE, SQUALAMINE, 2-methoxy-oestradiol (estradiol), vitaxin and marimastat.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
The patient's living cancer cells are tested to determine exactly which various chemotherapeutic, immunologic, molecularly-targeted, and anti-angiogenic drugs and drug combinations most effectively kill their cancer cells and which do not.
"Anti-angiogenic drugs stop tumours from growing their own blood vessels, and this, in turn, can slow the growth of cancer, or shrink it.
Furthermore, alternative therapies such as anti-angiogenic drugs, laser therapy, Photodynamic Laser Therapy (PTD), and vitamins fails to completely cure Age Related Macular Degeneration and Retinitis Pigmentosa, thus giving momentum to the bionic eye market.
Moreover, alternative therapies such as anti-angiogenic drugs, laser therapy, Photodynamic Laser Therapy, and vitamins fail to completely cure AMD and RP.
As for adjuvant setting, combined chemotherapy was the most preferred approach, and the common medications were anthracyclines, ifosfamide and dacarbazine; only 1 patient was treated with anti-angiogenic drugs sunitinib with a PFS of 9 months.
Anti-angiogenic drugs hold a promise for both indications and present a distinct perspective in endometriosis treatment.
Moreover, several anti-angiogenic drugs (ZD6474, AZD2171 and vatalanib/PTK787) are currently being under clinical trials (Hanrahan and Heymach 2007; Scot et al.
In the Research and Development area, the company completed key pilot studies on novel anti-angiogenic drugs and filed US and foreign patent applications for these agents.
Of particular interest is the identification of osteopontin (SPPI) as upregulated in poor outcome stroma, as we are in an era of large randomised clinical trials using potent bisphosphonate and anti-angiogenic drugs for breast cancer patients in the adjuvant setting.
Table 1: Anti-angiogenic drugs that target the vascular endothelial growth factor pathway.
Agricultural Center, Baton Rouge) notes that research on angiogenesis has attracted food scientists as well as molecular biologists, biomedical researchers, and others to this new field focusing on bioactive compounds that can serve as the basis for anti-angiogenic drugs or functional foods.