anti-Yo antibody

anti-Yo antibody

polyclonal IgG autoantibody directed against Purkinje's cells and associated with paraneoplastic cerebellar degeneration in oat cell carcinoma of the lung and cancer of the breast or ovary. Also called anti-Purkinje cell antibody.
References in periodicals archive ?
We present a case of paraneoplastic cerebellar ataxia (PCA) associated with anti-Yo antibody (anti-Purkinje cell antibody) due to an underlying gynecologic malignancy.
A serum paraneoplastic panel was positive for anti-Yo antibody with a high titer (Table 1).
Intrathecal synthesis of autoantibodies is a frequent finding in PCA patients with anti-Yo antibody (7).