anti-Scl-70

anti-Scl-70

Anti-scleroderma or anti-topoisomerase I antibody Immunology An autoantibody that occurs in Pts with scleroderma. See Scleroderma.
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17) Similarly, our patient had ANA-positive with 1/320 thin granularity and anti-Scl-70 negative.
The presence of taut, thin skin causing contractures; Raynaud phenomenon; esophageal dysmotility; restrictive lung disease; and the autoantibodies anticentromere and anti-Scl-70 is used to further confirm and distinguish different subtypes of systemic sclerosis.
ANA, anti-ds-DNA, anti-La, anti-Sm, anti-Scl-70, anti-Jo, anti-histon antikorlari ile anti-HIV ve anti-HCV antikorlari negatif olarak elde edildi).
The laboratory tests performed for the differential diagnosis were all negative (vitamin B12, anti-HIV, VDRL-RPR/TPHA, protein C, protein S, antithrombin III, lupus anticoagulants, factor V Leiden mutation, anti-histone ab, antinucleosome ab, anti-Sm ab, anti-U1 snRNP ab, anti-SS-A ab, antiSS-B ab, anti-Scl-70, anti-centromere ab, anti-Jo1 ab, ANA, anti-ds DNA, anti-cardiolipin ab IgM and IgG).
Binding of anti-Scl-70 to chromatin (6) and the patient's ethnic background may also account for these differences.
A complete blood count, serum chemistry, liver function tests, serum angiotensin converting enzyme (ACE) level, anti-Scl-70 antibody, serum complement levels, rheumatoid factor, and erythrocyte sedimentation rate were normal.
Occasionally, anti-Scl-70 and Jo-1 tests are performed but usually not before the others.
The ENA-4 profile detects Anti-SS-A, Anti-SS-B, Anti-Sm, and Anti- Sm/RNP, while the ENA-6 profile detects these four autoantibodies plus Anti-Scl-70 and Anti-Jo-1.
Anti-SSA and anti-SSB antibodies are found in Sjogren Syndrome (SS), anti-Sm antibodies are found in systemic lupus erythematosus (SLE), anti-RNP antibodies are found in mixed connective tissue disease (MCTD), and anti-Scl-70 antibodies are found in scleroderma.
The CRP was analyzed using a particle-enhanced immunoturbidimetric assay (Tina-quant C-reactive protein, Roche Diagnostics, Switzerland), and the ANA and ACA were assessed via indirect immunofluorescence on HEp-2 cells (cut-off value: 1:40) while the anti-SCL-70 was determined using immunoblot testing (EUROLINE anti-ENA profile 1).
Systemic sclerosis is associated with several autoantibodies such as anti-nuclear antibodies (ANA), ACA, anti-Scl-70 (anti-topoisomerase I) antibodies, anti-nucleolar antibodies (ANoA), etc.
Anti-Scl-70 (due to antibodies directed against topoisomerase) and ANAs with an anticentromere pattern are highly associated with progressive systemic sclerosis (the diffuse form of scleroderma) and CREST syndrome, respectively.