Both LV and RV longitudina peak systolic strain and strain rate values were similar among patients according to disease subset, anti-Scl-70
, the presence of digital ulcer, or interstitial lung disease.
Other positive anti-bodies included Anti-Ro, Anti La in 4 (20%) patients, Anti-Scl-70
in 2 (10%) and Anti-DsDNA in 4 (20%) patients, while Anti-smith, Anti-centromere remained negative in all (Figure-2).
Vasculitic markers (ANA, p-ANCA, c-ANCA, anti-ds-DNA, AMA, ASMA, anti-Scl-70
, anti-Jo-1, anti-SSA, anti-SSB), anti-acetylcholine receptor antibody and infectious serologic markers (hepatitis B surface antigen, herpes simplex virus type 1 and type 2 IgM anti-HIV, Brucella, Varicella-Zoster virus IgM, anti-HCV, VDRL-RPR) were negative.
Anti-ENA research is used to identify a group of specific autoantibodies, including anti-SSA/Ro, anti-SSB/La, anti-RNP, anti-Sm, anti-Scl-70
, anti-Jo-1, anti-CENP-B, anti-NUC, and anti-dsDNA.
The test for antinuclear antibodies (ANA) was positive (1:240), whereas the results for anti-double-stranded deoxyribonucleic acid (anti-dsDNA), anti-Smith (anti-Sm), anti-ribonucleoprotein (anti-RNP), anti-topoisomerase I (anti-Scl-70
), rheumatoidfactor (RA), and anti-Jo-1 antibodies were negative.
Among the anti-ENA autoantibody subtypes, anti-ACA was seen in 37% of patients, anti-Scl-70
in 24%, anti-RNP in 9%, and anti-RNAPIII in 5%; other subtypes were rarer.
One year after finishing this treatment, she was feeling well and had no significant dyspnea or difficulty swallowing, but the skin changes of her fingers compatible with scleroderma persisted and SSA antibodies remained high-titer positive, while anti-RNA-polymerase III, anti-centromere, and anti-SCL-70
antibodies were negative.
All the patients' sera were analyzed for the anti-SmD1[sub]83-119, anti-Sm, anti-U1-nRNP, anti-double-stranded DNA (dsDNA), anti-nucleosome, anti-SSA/Ro60, anti-SSA/Ro52, anti-SSB, anti-Scl-70
, and anti-histone antibodies using the immunoblotting assay.
(2) The presence of either anticentromere antibodies (ACA) or anti-Scl-70
is highly specific (95%-99%) for the diagnosis of ISSc and dSSc, respectively.
ANA anti dsDNA anti LKM Anti-SMA AMA C-ANCA P-ANCA anti-SSA anti-SSB anti-Scl-70
anti Jo-1 anti-U1snRNP anti- centromere anti-Jo-1 anti tpo and anti tg were studied in all individuals in each study group.
Anticardiolipin, anticentromere and anti-Scl-70
antibodies in patients with systemic sclerosis and severe digital ischaemia.
She was negative for Anti-SSA/SSB, Anti-DNA, Anti-sm, Anti-nRNP, Anti-Jo-1, Anti-histone, and Anti-Scl-70
. Hepatitis panel was also negative, and complement C3 and C4 levels were normal.