anti-Ro

anti-Ro

A non-organ specific IgG (IMMUNOGLOBULIN G) autoantibody directed against a soluble ribonucleoprotein. It is associated with SJÖGREN'S SYNDROME and other connective tissue disorders. Maternal anti-Ro can reach the fetal heart via the placenta during pregnancy and cause damage to the conducting system, resulting in congenital heart block.
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NLE is a rare form of systemic lupus erythematosus (SLE) believed to be caused by transplacental transfer of anti-Ro (Sjogrens syndrome antigen A, SSA), or less commonly, anti-La (Sjogrens syndrome antigen B, SSB) from mothers who are positive for these antibodies.
NLE is a rare form of systemic lupus erythematosus (SLE) believed to be caused by transplacental transfer of anti-Ro (SSA), or less commonly, anti-La (SSB) from mothers who are positive for these antibodies.
Mother-derived anti-Ro antibodies may have cross-reactivity with fetal epitopes on calcium-regulating molecules, such as ion channels.
NLE does not present in all offspring of Anti-Ro and Anti-La autoantibody positive mothers in a uniform manner hence a wide spectrum of manifestations may be seen even in twins or triplets as in our case.
Patient with erythema multiforme also had SCLE, positive ANA, Anti-Sm antibody, Anti-Ro antibody and satisfied the ACR criteria for diagnosis of SLE.
Demographic data, clinical findings, organ involvement, serological test results (for ANA, anti-ds-DNA, anti-Sm, anti-RNP, anti-Ro, and anti-La), complement levels, antiphospholipid antibodies (IgG and lgM anticardiolipin, lupus anticoagulant) detailed hematological testing, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels at the time of diagnosis, immunosuppressive agents including corticosteroids that patients may have taken during the entire follow-up, and presence of cumulative antiphospholipid syndrome (APS) (as diagnosed according to the 2006 Sapporo criteria) (6) were recorded as obtained from the patient files and electronic registry system.
La serologia puede ser positiva para anticuerpos anti-Ro y anti-La hasta 25% (2), y se manifiesta como una enfermedad sistemica con afectacion extraglandular, vasculitis cutanea, afectacion hepatica o renal, sinovitis, neuropatia periferica y enfermedad pulmonar intersticial.
Anti-nuclear antibody (ANA), anti-double stranded DNA (anti-ds DNA), anticardiolipin, anti-Ro, anti-La, and anti-Scl antibodies were within normal limits.
Anticardiolipin immunoglobulin (Ig)-G and IgM antibodies, lupus anticoagulant, anti-Ro, anti-La, anti-Sm antibodies, and the venereal disease research laboratory (VDRL) test were negative.
Este ultimo reporta ANAS 1/1280 patron moteado, ENAS con anti-Ro y anti-La positivos, factor reumatoide negativo y biopsia de la glandula salival con infiltracion linfocitaria en dos focos, que se diagnostica sindrome de Sjogren primario.
Additional laboratory investigation revealed negative antinuclear antibodies, as well as negative anti-double-stranded DNA, anti-Smith, anti-Ro, anti-La, and anti-neutrophil cytoplasmic antibodies.
8] Recent data suggest that hydroxychloroquine during pregnancy may reduce the incidence of congenital CHB in women with anti-Ro and anti-La antibodies.