anti-Ro

anti-Ro

A non-organ specific IgG (IMMUNOGLOBULIN G) autoantibody directed against a soluble ribonucleoprotein. It is associated with SJÖGREN'S SYNDROME and other connective tissue disorders. Maternal anti-Ro can reach the fetal heart via the placenta during pregnancy and cause damage to the conducting system, resulting in congenital heart block.
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References in periodicals archive ?
Over the following years, anti-Ro and anti-La tests remained highly positive and are up to the present.
Complete autoimmune serological marker panel including anti-Ro and La, lip biopsy, schirmer test, cerebrospinal fluid pressure, oligo clonal bands analysis and MRI brain with contrast was performed on all patients.
Antinuclear antibody, anti-double stranded DNA, anticardiolipin IgM and IgG, anti-topoisomerase I, anti-Smith antibody and Anti-Ro antibodies studied for other autoimmune disorders were negative.
C3 and C4 levelswere decreased but the rest of the rheumatologic panel (anti-dsDNA, Anti-Ro, Anti-La, Anti-SM, Anti-RMP and antineutrophil cytoplasmic antibodies) was negative.
Few studies have reported presence of autoantibodies related to rheumatic diseases, such as anti-Ro, anti-La, anti-Ds DNA, ANA and RF in sera of patient with malignancies.8
Other positive anti-bodies included Anti-Ro, Anti La in 4 (20%) patients, Anti-Scl-70 in 2 (10%) and Anti-DsDNA in 4 (20%) patients, while Anti-smith, Anti-centromere remained negative in all (Figure-2).
Anti-Ro antibodies, including anti-Ro60 antibodies, are found in about half of SLE patients and are the most common antinuclear antibodies that can be seen preclinically.
NLE is a rare form of systemic lupus erythematosus (SLE) believed to be caused by transplacental transfer of anti-Ro (SSA), or less commonly, anti-La (SSB) from mothers who are positive for these antibodies.
(38) Fetal loss was significantly higher in patients with APLA, lupus nephritis, anti-Ro antibody, hypertension, and a history of intravenous cyclophosphamide.
SP-1, CA6, and PSP are considered early stage markers for SS [1] than anti-Ro and anti-La.
Mother-derived anti-Ro antibodies may have cross-reactivity with fetal epitopes on calcium-regulating molecules, such as ion channels.
Other immunologic markers for which patients may test positive include anti-cardiolipin antibodies, lupus anticoagulant, anti-dsDNA, myeloperoxidase, and anti Sjogren's-syndrome-related antigen A (also known as anti-Ro) antibodies.