Eiger now has multiple active anti-HDV
agents in development, including an oral therapy and a subcutaneous injectable therapy to study alone and in combination toward the suppression or cure of HDV.
The selected HBsAg-positive serum samples were retrospectively tested for the presence of total anti-HDV antibodies using the commercially available enzyme-linked immunosorbent assay ETI-AB-DELTAK-2 (DiaSorin, Saluggia, Italy) with 99.
Total anti-HDV antibodies were detected in three of 1,305 patients with chronic HBV infection (0.
7 mg/dl in females), HBsAg Reactive, Anti-HCV Non-Reactive, Anti-HDV
Reactive, HBV-DNA by PCR Detected, HDV-RNA by PCR Detected.
antibody assay is highly recommended in HIV patients co-infected with HBV, particularly in those who live in endemic regions for HDV.
Of these, 294 were subsequently screened by using ELISA for anti-HDV
IgG; reactive samples were tested for HDV IgM.
HBsAg positive samples were tested for anti-HBc IgM, HBeAg, anti-HBe, anti-HCV and total anti-HDV
by electrochemiluminescence immunoassay (ECLIA), using the Cobas[R] e601 analyzer (Roche Diagnostics, Mannheim, Germany), according to manufacturer's instructions.
2%) were positive for both HBsAg and anti-HDV
Serum of patients with acute viral hepatitis was investigated by ELISA for the presence of anti-HDV
IgM, anti-HBc IgM, HBsAg, anti-HCV IgM, total anti-HCV, anti-HDV
IgM, anti-E2HGV using the test kits produced by "Vector Best" CJSC (Novosibirsk, Russia).
typically appears 6-7 weeks after exposure, remains elevated during the acute phase of the illness and then declines.
All HBsAg-positive samples were tested for HBeAg (hepatitis B e-antigen) and anti-HBe (antibody to hepatitis B e-antigen) to assess the infectivity status and also anti-HDV
(antibody to hepatitis D virus) to assess co-infection with the delta agent.
A test to detect total anti-HDV
is commercially available.