The appearance of anti-HBe
is indicative of lower infectivity.
Venous blood samples of 3 cc were obtained from these children and their HBV markers (HBsAg, anti-HBs, HBeAg, anti-HBe
, anti-HBclgM, ve anti-HBclgG) were tested with the Enzyme-Linked Immunosorbent Assay method.
The ARCHITECT system offers 12 assays for hepatitis A, B and C outside the US: HBsAg, HBsAg Confirmatory, HBsAg Quantitative, HBeAg, Anti-HBe
, HAVAb IgG, HAVAb IgM, Anti-HBc, Anti-HBc IgM, Anti-HBs, Anti-HCV and HCV Ag.
occurs shortly after the disappearance of HBeAg and indicates that the patient is recovering from HBV infection.
usually reflects diminished viral replication.
Among 95 mothers whose serum contained anti-HBe
, viral loads ranged between undetectable and 8.
Moreover, the patient achieved neither HBeAg seroconversion to anti-HBe
nor normalization of ALT during the entire period of treatment, except for month 12, when her ALT concentration decreased to 33 IU/L (the upper limit of normal was 35 IU/L).
Associated with the loss of HBeAg, or a fall or loss of the HBV DNA concentrations, the appearance of anti-HBe
, and histologic evidence of a decrease in inflammatory activity.
The Elecsys automated platform (Roche) was used to screen for HBeAg and anti-HBe
before the onset of treatment and at 44 weeks after the initiation of treatment to evaluate seroconversion from HBeAg to anti-HBe
Yatisinda alinan viral serolojik tetkiklerden; Anti-HAV IgM pozitif, IgG negatifti; HBsAg, anti-HBs, anti HBc IgM, HBeAg ve anti-HBe
Most HBV carriers will clear HBeAg, produce anti-HBe
(antibodies to hepatitis B e antigen), and progress to the inactive carrier state.
Seroconversion to anti-HBe
occurred in 23% of the patients across dosage groups.