anti-GBM disease

anti-GBM disease

a rare autoimmune disease; kidney or pulmonary disorder in which the glomerular basement membrane is damaged by an antigen-antibody reaction. The kidney itself may serve as the antigenic target in the reaction. Also called Goodpasture's disease.
References in periodicals archive ?
In this setting, patients have a worse prognosis than ANCA isolated conditions, with a clinical course more similar to pure anti-GBM disease.
Anti-GBM disease has similar features on light microscopy, with the addition of positive linear basement membrane staining with IgG in the glomeruli.
Anti-GBM disease is a diagnosis that is made when there is a presence of circulating anti-GBM antibodies in the serum.
Seronegative anti-GBM disease has been previously described and mostly blamed for the relative insensitivity of earlier serologic assays.
Here we present a case of seronegative anti-GBM disease with a positive p-ANCA serology.
There was bright linear glomerular basement membrane staining with IgG consistent with anti-GBM disease (Fig 2).
The prognosis in mixed ANCA and anti-GBM disease is similar to that of pure anti-GBM disease.
In anti-GBM disease, the likelihood of renal recovery correlates with the serum creatinine and need of dialysis at initial presentation.
Cases of isolated pulmonary involvement and seronegative anti-GBM disease were described previously.
The treatment of anti-GBM disease focuses on a combination of plasma exchange, cyclophosphamide, and prednisone.
Patient monitoring for ITP, thyroid disorders and anti-GBM disease is incorporated into all Genzyme-sponsored trials of alemtuzumab for the treatment of multiple sclerosis.
The other pathologic entities that can lead to crescentic GN are anti-GBM disease and immune complex-mediated GNs that have been discussed previously (see above).