anthrax toxin


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an·thrax tox·in

a culture filtrate of Bacillus anthracis containing an exotoxin with at least three different antigenically distinct components: edema factor, lethal factor, and protective antigen.

anthrax toxin

The three proteins made by the infectious bacterium Bacillus anthracis responsible for the deadly effects of anthrax. Anthrax toxin includes protective antigen, which helps lethal and edema factors enter and kill cells by disrupting the cell membrane's normal biochemical functions.
See also: toxin
References in periodicals archive ?
Researchers have coupled anthrax toxins with chemotherapy to form a remedy that will shrink or eliminate cancerous tumours.
A way in Anthrax toxin from the Bacillus anthracis bacterium is composed of three proteins, called protective antigen, edema factor and lethal factor.
Professor Stanley Cohen, the senior author of the new study, and his colleagues found that variation in the level of expression of a gene that produces a cell-surface protein called CMG2 affects the success of the anthrax toxin in gaining entry into human cells.
Valortim is designed to target anthrax protective antigen and protect the cells from damage by the anthrax toxins.
Ultimately, the researchers found that two of the 145 peptides fit the bill: Each peptide elicited antibodies when injected into mice, and these antibodies protected macrophages from death that would normally have occurred when the macrophages were exposed to anthrax toxin.
ProThera's novel, proprietary technology is focused on blocking the harmful anthrax toxin, and preventing the severe - usually fatal - inflammation that follows.
The scientists injected two different doses of the liposomes into two groups of nine rats, each of which had just been injected with anthrax toxin.
Initially, he was classified as having a suspected case because of a lesion on his left hand and elevated levels of antibody (lgG) to the protective antigen component of anthrax toxin.
But scientists at Porton Down, who tested blood samples from five Scots victims, said two tested positive for the main anthrax toxin, Protective Antigen.
It is claimed two users, including one recent victim, tested positive for the main anthrax toxin.
Meanwhile, another group presents new findings about how anthrax toxin kills.
Serial serum samples, obtained on October 7, 10, 11, and 17, indicated a serum IgG antibody response to the PA component of the anthrax toxin consistent with acute B.