Passively transferred antibodies can neutralize anthrax toxins
and can be used post-exposure in conjunction with antibiotics.
Researchers have known that anthrax toxin
damages blood vessels, resulting in internal bleeding and a buildup of fluid around the lungs that impedes breathing.
Testing for serum IgG antibody response to the PA component of the anthrax toxins
was offered on October 10, 13, 17, and 19 to workplace-exposed persons.
The investigators speculate that the anthrax toxin
could be modified into a drug that dampens immune responses.
The reactivity threshold was determined empirically, avoiding assumptions on the antibody response rate following exposure to anthrax toxin
PA whether by vaccination or clinical infection.
The most likely mechanism of action by which antibodies to anthrax toxin
proteins mediate protection is binding to toxin and impeding its interaction with the host cell.
Images depict the molecular structure of edema factor, a component of the anthrax toxin
Also, scientists located the protein to which the anthrax toxin
attaches when it attacks a cell (160: 260 (*)).
The ATCC([R]) Standards Development Organization (ATCC SDO), an entity of ATCC, has published its first voluntary consensus standard, ASN-0001: "Standardization of In Vitro Assays to Determine Anthrax Toxin
OTCQB: SNGX) (Soligenix or the Company), a late-stage biopharmaceutical company developing products that address unmet medical needs in the areas of inflammation, oncology and biodefense, announced today the publication of data demonstrating that the combination of RiVax(TM) and VeloThrax(TM) induces protective immunity to both ricin toxin and anthrax toxin
Scientists have identified the protein that enables the anthrax toxin
to attach to cells and trigger disease.
These findings could lead to an antidote to the anthrax toxin
and help clarify the mechanism by which it kills.