anthrax toxin


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an·thrax tox·in

a culture filtrate of Bacillus anthracis containing an exotoxin with at least three different antigenically distinct components: edema factor, lethal factor, and protective antigen.

anthrax toxin

The three proteins made by the infectious bacterium Bacillus anthracis responsible for the deadly effects of anthrax. Anthrax toxin includes protective antigen, which helps lethal and edema factors enter and kill cells by disrupting the cell membrane's normal biochemical functions.
See also: toxin
References in periodicals archive ?
Researchers have coupled anthrax toxins with chemotherapy to form a remedy that will shrink or eliminate cancerous tumours.
A way in Anthrax toxin from the Bacillus anthracis bacterium is composed of three proteins, called protective antigen, edema factor and lethal factor.
Oh et al., "An anthrax lethal factor-neutralizing monoclonal antibody protects rats before and after challenge with anthrax toxin," Infection and Immunity, vol.
Professor Stanley Cohen, the senior author of the new study, and his colleagues found that variation in the level of expression of a gene that produces a cell-surface protein called CMG2 affects the success of the anthrax toxin in gaining entry into human cells.
Identification of anthrax toxin genes in a Bacillus cereus associated with an illness resembling inhalation anthrax.
Using a submicroscopic packet called a liposome, scientists neutralized anthrax toxin in rats (16.9: 262).
Specific, sensitive, and quantitative enzyme-linked immunosorbent assay for human immunoglobulin G antibodies to anthrax toxin protective antigen.
Even the anthrax toxin is being evaluated as a choice for tumor cell surface targeting in chemoresistant neoplasms (5).
Two victims showed weak signs of the main anthrax toxin in tests at the top-secret Porton Down base in England but Greater Glasgow Health Board were quick to allay fears of an epidemic.
The Porton Down scientists said two of the victims' blood samples tested positive for main anthrax toxin, Protective Antigen.
ProThera's novel, proprietary technology is focused on blocking the harmful anthrax toxin, and preventing the severe - usually fatal - inflammation that follows.
Ultimately, the researchers found that two of the 145 peptides fit the bill: Each peptide elicited antibodies when injected into mice, and these antibodies protected macrophages from death that would normally have occurred when the macrophages were exposed to anthrax toxin.