anthrax lethal factor

anthrax lethal factor

(an'thraks lē'thăl fak'tŏr),
A protein secreted by Bacillus anthracis, that selectively induces apoptosis of activated macrophages by cleaving the amino-terminal extension of mitogen-activated protein kinase kinases (MKKs). This action may allow the bacteria to avoid detection by the host's innate immune system.
References in periodicals archive ?
Validation of rapid, sensitive, quantitative MALDI-TOF MS assays for anthrax lethal factor and lethal toxin.
Structural basis for the unfolding of anthrax lethal factor by protective antigen oligomers.
Murine mAb against anthrax lethal factor (LF8) was developed and purified in our lab, as described previously [20].
Crown et al., "Novel chimpanzee/ human monoclonal antibodies that neutralize anthrax lethal factor, and evidence for possible synergy with anti-protective antigen antibody," Infection and Immunity, vol.
Cao, "Neutralizing monoclonal antibody against anthrax lethal factor inhibits intoxication in a mouse model," Human Antibodies, vol.
Duesbery, "Biological and biochemical characterization of anthrax lethal factor, a proteolytic inhibitor of MEK signaling pathways," Methods in Enzymology, vol.
Bound to these molecules is a protein fragment, or peptide, that gets cleaved in two in the presence of anthrax lethal factor, a toxin produced by the bacterium.
After screening 10,000 chemicals in 3 days, the researchers found one compound, called DS-998, that blocked the activity of anthrax lethal factor. In a subsequent test, the compound protected lab-grown human cells that later were exposed to the toxin.