anthracenedione

anthracenedione

 [an″thrah-sēn-di´ōn]
any of a class of derivatives of anthraquinone; some have antineoplastic properties; the group includes mitoxantrone hydrochloride.

anthracenedione

/an·thra·cene·di·one/ (an″thrah-sēn-di´ōn) any of a class of derivatives of anthraquinone, some of which have antineoplastic properties.
References in periodicals archive ?
For example, PZ-39 (N-(4-chlorophenyl)-2-[(6-{[4,6-di(4-morpholinyl)-1,3,5-triazin-2- yl]amino}-1,3-benzothiazol-2-yl)sulfan- yl]acetamide), an acetamide-containing compound, has been reported to significantly enhance the anti-breast-cancer activity effect of mitoxantrone, an anthracenedione [14].
Mitoxantrone is a synthetic antineoplastic anthracenedione initially approved for the treatment of acute myeloid leukaemia in 1987.
Novantrone is a synthetic anthracenedione that acts as a Topo II inhibitor and a DNA intercalator.
Examples of drugs containing the 9, 10- anthracenedione moiety include: doxorubicin and mitoxantrone (McClendon and Osheroff 2007).
Thin layer chromatography was performed to detect anthraquinones in cell and supernatant extracts by using of 9,10- anthracenedione and 1-hydroxy-4methylanthaquinone standards (1 mg x [ml.
The anthraquinones of interest, 9,10- anthracenedione and 1-hydroxy-4methylanthaquinone could not be detected in control (unelicited) and elicited culture extracts when the TLC plate sprayed with p-anisaldehyde (Figure 6).
Pixantrone, the Company s clinical trial product for the treatment of non-Hodgkin s lymphoma and other hematologic malignancies, and solid tumors, is the first aza-anthracenedione to reach advanced clinical development, and was designed to improve the efficacy, and reduce the toxicity, associated with anthracyclines and anthracenediones.
Antitumour antibiotics directly inhibit DNA replication, and comprise anthracyclines, such as doxorubicin, idarubicin, epirubicin, and the anthracenedione mitoxantrone.
It included 447 patients who were refractory to, or had relapsed following, first-line treatment with rituximab in combination with a chemotherapy regimen containing anthracycline or anthracenedione.
Multidrug resistance protein 1 (MRP1), which is structurally similar to P-gp, is the product of the ABCC1 gene and can export anthracenedione, anthracycline, epipodophyllotoxin, vinca alkaloids, etc.
Novantrone(R) is a synthetic antineoplastic anthracenedione used intravenously as an anti-cancer agent.