The flare OD had resolved but persistent +1 flare OS was still present, indicating mild anterior uveitis
. The intraocular pressure was within normal limits OU (14 mm Hg OD, 15 mm Hg OS).
Lymphocytic anterior uveitis
has been described in ocular infections with other viruses (e.g., rubella virus, cytomegalovirus, herpes simplex virus, and chikungunya virus) and can indicate a secondary immune response to viral antigens (31,32), although the pyknotic debris and swollen endothelium in the new vessels at the corneal margin in LASV-infected guinea pigs suggest a more acute insult.
(15) reported 5 patients who developed hypotony and serous retinal detachment secondary to HLA-B27-associated anterior uveitis
, while Roe et al.
In our study, subconjunctival hemorrhages in and/or dilation of the conjunctival and scleral vessels (described as red eyes) were the most common manifestation, followed by symptomatology suggestive ofconjunctivitis, then by unilateral red eye, ciliary flush, irregular pupil(s), which might suggest the symptomatology of anterior uveitis
, and, lastly, unilateral vision loss with floaters, which might also suggest posterior segment involvement.
In our cases, anterior uveitis
and bilateral uveitis were observed in 60% and 100%, respectively.
Although intravitreal injection is not a common treatment modality for anterior uveitis
in clinical practice, we think this may be a good choice to provide good intraocular concentration and reduce the suffering of the animals during this exploratory experiment.
Wakefield, "Acute anterior uveitis
and HLA-B27," Survey of Ophthalmology, vol.
The conditional recommendation was for patients with isolated anterior uveitis
. When these patients have markers of a poor prognosis such as young age, male sex, or early disease onset--systemic treatment with an immunosuppressant is a possible option.
Current approach in diagnosis and management of anterior uveitis
. Indian J Ophthalmol.
Rheumatic diseases have many similar symptoms, and also can affect other organs, including the bowels, (inflammatory bowel disease, Crohn's disease) skin (psoriasis), the eyes (anterior uveitis
), kidneys, nervous system, and heart and blood vessels.
Anamnesis revealed similar bilateral episodes that were diagnosed as conjunctivitis or anterior uveitis
. All episodes were treated with antibiotics and non-steroidal anti-inflammatory eye drops each time, without thorough investigations over the causes.