DTI analysis revealed a significant increase in mean, radial, and axial diffusivity, mainly of the fibers of bilateral anterior thalamic radiation and superior longitudinal fasciculus with left predominance, which intersected with bilateral subinsular white matter (P < 0.
White matter alterations were observed within bilateral anterior thalamic radiation and superior longitudinal fasciculus that intersects with subinsular white matter.
2), increased MD in bilateral superior longitudinal fasciculus with left predominance and bilateral anterior thalamic radiation (cluster in left hemisphere: t=5.
In this study, we found that patients diagnosed with schizophrenia had increased AD, MD, and RD values corresponding to left and right superior longitudinal fasciculus and anterior thalamic radiation.
In addition to this, a meta-analysis which combined findings from 15 DTI studies reported two main regions in schizophrenia patients: left frontal and temporal white matter including anterior thalamic radiation (33).
The results of our study showed increased MD values within bilateral anterior thalamic radiation and superior longitudinal fasciculus, in addition to greater RD values within the left anterior temporal lobe and greater AD within the left superior longitudinal fasciculus.