Delivery of NAV AAV8-based gene therapy through the suprachoroidal space, provides a targeted, in-office, non-surgical approach to obtain widespread transgene expression in retina, without having to expose the vitreous and anterior segment of the eye
to the injected drug, according to the companies.
Delivery of NAV AAV8-based gene therapy through the suprachoroidal space can potentially provide a targeted, in-office, non-surgical approach to obtaining widespread transgene expression in the retina without exposing the vitreous and the anterior segment of the eye
to the injected drug.
Biopharmaceutical company Oculis SA revealed on Thursday the launch of an agreement to in license a novel topical anti-TNF alpha antibody,named LME 636, from Novartis for treating inflammatory conditions of the anterior segment of the eye
including Dry Eye Disease.
Ocular complications involving the anterior segment of the eye
include subconjunctival haemorrhageand rarely anterior uveitis.
Flarex, approved in the United States, is indicated for the treatment of steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the eye
In PXS, a fibrillar extracellular material is produced and becomes distributed around the anterior segment of the eye
. (10) The exact source is unknown but is thought to possibly originate from epithelial cells of the iris, lens and ciliary body.
PXE material is associated with many organs such as the lung, skin, liver, heart, and kidney in the body, but it manifests as a disease only in the eye, where flakes of material are present at the edge of the pupil, on the lens and on iris, in the drainage parts and other structures primarily in the anterior segment of the eye
. When this PXE material gets clogged in the eye's drainage system, the ocular pressure can rise and lead to glaucoma, and also if the material gets deposited on the structures like zonules, which hold the lens in place, and are weaker, it would increase the risk of complications during cataract surgery.
* Anterior segment of the eye
was examined using a torch light/ slit lamp.
The aim of the study was to determine the effect of blepharospasm as a protective factor on the anterior segment of the eye
by comparing the stage of the disease and ocular surface changes.
Anterior segment dysgenesis occurs when the structures of the anterior segment of the eye
are affected, such as the cornea, iris and lens, anterior chamber and posterior chamber, trabecular meshwork, and Schlemm's canal .
In this condition, the anterior segment of the eye
has normal depth and angle configuration.