antagonistic effect

antagonistic effect

The negative effect that one chemical or family of chemicals has on other chemicals.

antagonistic effect

The negative effect that one chemical or family of chemicals has on other chemicals
References in periodicals archive ?
The mechanism of the combination pattern of these prescriptions should also be investigated whether additive, synergistic or antagonistic effect exist using in vitro or in vivo models.
When combined with PG, it was observed that an antagonistic effect was initiated upon CG since the [EC.
To investigate mechanistically the antagonistic effect of BPA and BPAF in the present study, we treated cells with lower doses of these EDCs (1 or 10 nM) in the presence of 10 nM E[E.
Based on the IE, the kind of pharmacodynamic interaction between the crude extracts and artesunic acid was determined from the criteria; synergistic effect (IE <1), additive effect (IE = 1), antagonistic effect (IE >1) (7).
2 represents a combined antagonistic effect on positive co-stimulation with an agonistic effect on negative signalling.
John's Wort Decreased effect Stimulation of cytochrome 2C9, which is responsible for metabolizing a major warfarin racemate Acerola/Vitamin C Antagonistic effect Excessive amounts of vitamin C associated with a procoagulant effect Fish Oils Synergistic effect Presumably through a decrease in platelet aggregation * Condensed from Natural Medicines Comprehensive Database, 2001 Table 4.
Because the drug suppresses growth rather than causing cell death, long-term therapy is required during which its weak estrogen antagonistic effect on the uterus can contribute to endometrial hyperplasia, polyp formation, and an increased risk for endometrial cancer, she explained.
However, several articles have reported that an antagonistic effect has been seen with the use of phosphate esters and antimony oxide.
On drug sessions where pentobarbital was given with picrotoxin, there was no additional or antagonistic effect of the picrotoxin.
Although protein levels were not measured in this study, our finding that L-THP reversed the METH-induced decrease in mRNA expression levels of D3 receptor may be explained by the fact that since L-THP has an antagonistic effect on DA D3, as well as D1 and D2 receptors (Figueroa-Guzman et al.
Furthermore, blocking the ACTH receptor with antibody did not interfere with the antagonistic effect of ATR on GH.