Protagonist) to develop, manufacture and commercialize PTG-200, a first-in-class, oral interleukin-23 receptor (IL-23R) antagonist drug
candidate in development for the treatment of Crohns disease and ulcerative colitis (UC).
The study is designed to evaluate the potential of GMI-1271, GlycoMimetics' E-selectin antagonist drug
candidate, in combination with chemotherapy, as a treatment for patients with both newly diagnosed and relapsed/refractory AML.
The various regimens use different combinations of periods of treatment with unfractionated heparin, low-molecular-weight heparin, or a vitamin K antagonist drug
during the first trimester, during weeks 14-36, and during the last weeks of pregnancy.
The implant then delivers therapeutic levels of the antagonist drug
, naltrexone, into the bloodstream which can curb one's cravings for alcohol or opioids.
Next, they blocked the activity of CXCR4 in the MPNST mice using either genetic manipulation or an FDA-approved antagonist drug
for CXCR4 called AMD3100.
An opioid antagonist drug
could be combined with a pain-killing narcotic but not be activated unless the patient tried to take too much of the narcotic or to take it too often.
The second quarter 2009 expense was higher due to the costs associated with the purchase of materials and manufacturing of HIF-1 alpha and survivin antagonist drug
supply for Phase I clinical trials.
Surgical removal of the testicles is the oldest method, while the newest option is the LHRH antagonist drug
PolyMedix plans to develop an antagonist drug
that is safer and easier to use than currently approved therapy.
Naltrexone is an opiate antagonist drug
developed in the 1970s and approved by the FDA in 1984 for opiate and drug abuse treatment.
The new Pharmacor report "Hypertension" finds that sales of Novartis's Tekturna, the first renin inhibitor that will be used to treat hypertension, will be bolstered if clinical trial data demonstrate that the drug can provide prevention of end-organ damage superior to that of the angiotensin II receptor antagonist drug
Physuline is an oral vasopressin V2-receptor antagonist drug
that has proven effective in patients with syndrome of inappropriate antidiuretic hormone (SIADH), a condition resulting in fluid overload due to the excessive release of antidiuretic hormone.