This patent broadens previously issued patent by expanding the use of Onvansertib to encompass combination therapies with any anti-androgen and androgen antagonist drug
for the treatment of metastatic and non-metastatic castrate-resistant prostate cancer.
The antagonist drug
the team gave the mice during their periods of isolation effectively lessened the negative effects of the isolation.
Rimonabant: an antagonist drug
of the endocannabinoid system for the treatment of obesity.
(Protagonist) to develop, manufacture and commercialize PTG-200, a first-in-class, oral interleukin-23 receptor (IL-23R) antagonist drug
candidate in development for the treatment of Crohns disease and ulcerative colitis (UC).
The study is designed to evaluate the potential of GMI-1271, GlycoMimetics' E-selectin antagonist drug
candidate, in combination with chemotherapy, as a treatment for patients with both newly diagnosed and relapsed/refractory AML.
Several methodologies are currently available for measuring serum TNF antagonist drug
concentrations and for detecting ADAs, which show significant variations in both analytical sensitivity and specificity (45-48).
If the former, studies would need to determine whether a person would benefit from treating OSA to reduce aldosterone levels; if the latter, whether a person would benefit from an aldosterone antagonist drug
to reduce the severity of OSA.
The 5HT3 receptor antagonist drug
granisetron, which is more potent and long acting than ondansetron against emesis associated with chemotherapy, have been found to be very effective for preventing PONV after laparoscopic cholecystectomy.
The various regimens use different combinations of periods of treatment with unfractionated heparin, low-molecular-weight heparin, or a vitamin K antagonist drug
during the first trimester, during weeks 14-36, and during the last weeks of pregnancy.
The implant then delivers therapeutic levels of the antagonist drug
, naltrexone, into the bloodstream which can curb one's cravings for alcohol or opioids.
Palosuran (ACT-058362), the only UT antagonist drug
candidate, when administered intravenously, protected against renal ischemia in a rat model .
Next, they blocked the activity of CXCR4 in the MPNST mice using either genetic manipulation or an FDA-approved antagonist drug
for CXCR4 called AMD3100.