ansamycins

ansamycins

Drugs used to treat TUBERCULOSIS. An example is rifabutin (Mycobutin).
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Request for quotations : Tests for 6 types of antibiotics: tetracyclines, -lactams, chloramphenicol, streptomycins, macrolides, ansamycins. (tests should work without incubators (heating))
Results for penicillin, [beta]-lactam inhibitor combination, glycopeptides, aminoglycoside, macrolides, fluoroquinolones, lincosamides, folate pathway inhibitors, phenicols, ansamycins, oxazolidinones, tetracycline, cephems, monobactams, carbapenems and lipopeptides were interpreted according to the breakpoints described in the Clinical Laboratory Standards Institute' guideline (16) and results emitted by the VITEK 2.
Neckers, "Inhibition of heat shock protein HSP90 pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation," Proceedings of the National Academy of Sciences of the United States of America, vol.
Neckers, "Inhibition of heat shock protein HSP90pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation," Proceedings of the National Academy of Sciences of the United States of America, vol.
Antimycobacterial activities of two newer ansamycins, R-76-1 and DL 473.
Anti-leprosy activity of ofloxacin and ansamycins in mice.
In addition to rifalazil, ActivBiotics expects to have a full pipeline of long lasting, extremely potent ansamycins with broad spectrum coverage in clinical development during this timeframe."
Rifalazil represents the lead compound in a new generation of ansamycin antibiotics, with very long acting antibacterial potency, to be commercialized by ActivBiotics.
In the 1970s, scientists isolated a family of natural antibiotics, called ansamycins, that microbes secrete--seemingly, to kill off competitors.
Inhibition of heat shock protein [Hsp90-pp60.sup.v-src] heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation.
Geldanamycin, heat shock protein 90-binding benzoquinone ansamycin, inhibits steroid-dependent translocation of the glucocorticoid receptor from the cytoplasm to the nucleus.
Maytansinoids, like rifamycin (Figure 1(a)) and geldanamycin (Figure 1(b)), which structurally belong to the ansamycin family of polyketide macrolactams are products of three closely related plant families (Celastraceae, Rhamnaceae, and Euphorbiaceae), mosses, and certain bacteria such as Actinosynnema pretiosum.