Shen, "A novel ansamycin
, naphthomycin K from Streptomyces sp.," The Journal of Antibiotics, vol.
Maytansinoids, like rifamycin (Figure 1(a)) and geldanamycin (Figure 1(b)), which structurally belong to the ansamycin
family of polyketide macrolactams are products of three closely related plant families (Celastraceae, Rhamnaceae, and Euphorbiaceae), mosses, and certain bacteria such as Actinosynnema pretiosum.
Rifamycin B is powerful, less toxic, and easily biodegradable antibacterial ansamycin
antibiotic  and is produced by strain of Nocardia mediterranei.
Rifalazil represents the lead compound in a new generation of ansamycin antibiotics, with very long acting antibacterial potency, to be commercialized by ActivBiotics.
In addition to rifalazil, ActivBiotics expects to have a full pipeline of long lasting, extremely potent ansamycins with broad spectrum coverage in clinical development during this timeframe."
Ono Y, Kozai Y, Ootsu K (1982) Antitumor and cytocidal activities of a newly isolated benzenoid ansamycin
, macbecin I Gann 73: 938-944
Geldanamycin, heat shock protein 90-binding benzoquinone ansamycin
, inhibits steroid-dependent translocation of the glucocorticoid receptor from the cytoplasm to the nucleus.
* Rifabutin (Ansamycin
, Mycobutin), Adria Laboratories
Among the viral inhibitors; suramin, HPA23, phosphonoformate, ribavirin, interferon, ansamycin
. Immunomodulators undergoing trails include interleukin-2.
STA-9090 is a potent, second-generation, small-molecule Hsp90 inhibitor, with a chemical structure unrelated to the first-generation, ansamycin
family of Hsp90 inhibitors.