ansamycin


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ansamycin

Any of a family of chemicals (e.g., the rifamycin family)
which have antibacterial, antitubeculous, antiviral and possibly also antineoplastic activity.
References in periodicals archive ?
Rifalazil represents the lead compound in a new generation of ansamycin antibiotics, with very long acting antibacterial potency, to be commercialized by ActivBiotics.
In addition to rifalazil, ActivBiotics expects to have a full pipeline of long lasting, extremely potent ansamycins with broad spectrum coverage in clinical development during this timeframe.
Ono Y, Kozai Y, Ootsu K (1982) Antitumor and cytocidal activities of a newly isolated benzenoid ansamycin, macbecin I Gann 73: 938-944
Geldanamycin, heat shock protein 90-binding benzoquinone ansamycin, inhibits steroid-dependent translocation of the glucocorticoid receptor from the cytoplasm to the nucleus.
Among the viral inhibitors; suramin, HPA23, phosphonoformate, ribavirin, interferon, ansamycin.
STA-9090 is a potent, second-generation, small-molecule Hsp90 inhibitor, with a chemical structure unrelated to the first-generation, ansamycin family of Hsp90 inhibitors.
Development of these early Hsp90 inhibitors, however, has been hampered by several drawbacks, including the hepatotoxicity associated with chemical properties of this ansamycin family of compounds.