Pharmacological mechanisms involved in reduced sperm quality and fertility in rats exposed to the anorexigen
sibutramine," PLoS ONE, vol.
In anorexia nervosa, the intestinally derived anorexigen
peptide YY is elevated, (13) which may contribute to bone loss.
Also, authors such as Flier (2006) have demonstrated that BCAA, especially leucine, can act on central receptors and signal anorexigen
peptide synthesis, probably via mTOR.
Reversible pulmonary hypertension associated with anorexigen
Two cases--one of an interest of large corporations (regulation of food advertising) and the other concerning more local interests (anorexigens
agents) involve questions of interest to Public Health and to protection of health, in which the final result benefited the interest of the sector being regulated and not the interest of public health.
Pulmonary arterial hypertension 1.1 Primary pulmonary hypertension (a) Sporadic (b) Familial 1.2 Related to (a) Collagen vascular disease (b) Congenital systemic-to-pulmonary shunts (c) Portal hypertension (d) Human immunodeficiency virus infection (e) Drugs/toxins (1) Anorexigens
(2) Other (f) Persistent pulmonary hypertension of the newborn (g) Other 2.
Risk factors for PAH include underlying connective tissue disease, especially limited scleroderma and mixed connective tissue disease, a family history of PAH, the presence of congenital heart disease, and environmental factors such as exposure to anorexigens
Or should we handle it the way previous anorexigens
were handled, with punitive measures?
Jollis et al., Fenfluramine and Phentermine and Cardiovascular Findings: Effect of Treatment Duration on Prevalence of Valve Abnormalities, 101 CIRCULATION 2071 (2000); Stuart Rich et al., Anorexigens
and Pulmonary Hypertension in the United States: Results from the Surveillance of North America Pulmonary Hypertension, 117 CHEST 870 (2000).
Germany referred its fears to the CPMP regarding anorexigens
, including medicinal products containing amfepramone, liable to cause serious pulmonary arterial hypertension.
Pulmonary arterial hypertension may be idiopathic and sporadic (IPAH), familial (FPAH), or associated with (APAH) connective tissue diseases, congenital systemic to pulmonary shunts, portal hypertension, HIV, drugs including anorexigens
or cocaine, and other disorders (Table 1).
Studies such as this one are important for understanding the background of higher valvular disease risk among the very people who would use anorexigens