anoikis


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anoikis

A type of programmed cell death (apoptosis) that is induced by a loss of correct cell/extracellular matrix attachment. Cells require intact integrin family receptors to suppress anoikis, and the process requires mitochondrial membrane permeabilisation; certain cells (e.g., epithelial and endothelial cells) are more resistant to anoikis.

Anoikis resistance can be induced through activation of extracellular signalling-receptor kinase (ERK) and the phosphatidylinositol 3-kinase (PI3K) signalling cascade by hepatocyte growth factor (HGF). Metastatic cells are resistant to anoikis and often have increased levels of the death receptor-inhibiting protein FLIP.

anoikis

(a-ny'-kis) [ ¹an- + Gr. oikia, house + -(s)is]
Programmed cell death occurring in epithelial cells. It is associated with loss of the normal ability to establish contacts between the cell and the extracellular matrix.
See: apoptosis

anoikis

a special form of APOPTOSIS, whereby cells undergo cell death after disruption of cell-matrix interactions. Anoikis ensures that cells are unable to survive in inappropriate locations. It occurs when epithelial cells (see EPITHELIUM are either not bound to the matrix via INTEGRINS or are bound via the wrong integrins. The process is also called detachment-induced cell death or suspension-induced apoptosis.
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References in periodicals archive ?
They had previously proposed the compensatory role of the av[beta]3 integrin receptor in anoikis (apoptosis induced by extracellular matrix disassembly) rescue in COL5A1 and COL3A1 mutations associated with cEDS and vEDS, respectively (33).
Levofloxacin increases the effect of serum deprivation on anoikis of rat nucleus pulposus cells via Bax/Bcl-2/caspase-3 pathway.
Neural precursor cell expressed, developmentally downregulated 9 (NEDD9) triggers mitotic checkpoint, regulates cellular attachment and migration, and ciliary resorption, but also apoptosis and anoikis, i.e.
A novel time resolved fluorometric assay of anoikis using Europium-labelled Annexin V in cultured adherent cells.
(3) Moreover, some studies showed that the adhesion capacity of highly metastatic cells could be reduced by inhibiting integrin expression or modifies the process that leads metastatic cells to anoikis, which is programmed cell death that is induced upon cell detachment from ECM.
Jararhagin, a snake venom toxin, induces a specialized form of apoptosis (anoikis) selective to endothelial cells.
Takahashi et al., "Peroxisome proliferator-activated receptor y inhibition prevents adhesion to the extracellular matrix and induces anoikis in hepatocellular carcinoma cells," Cancer Research, vol.
Yang et al., "Midkine promotes hepatocellular carcinoma metastasis by elevating anoikis resistance of circulating tumor cells," Oncotarget, vol.
Seo, "Salinomycin promotes anoikis and decreases the CD44+/CD24stem-like population via inhibition of STAT3 activation in MDA-MB-231 cells," PLoS One, vol.
By binding to cell surface receptors, laminin induces different signal transduction pathways, which influence cell behavior such as adhesion, differentiation, migration, phenotype stability, and resistance to anoikis [9].
On the other hand, once a tumor is established, autophagy serves a cell survival function in cancer cells that helps them survive hypoxia, metabolic stress, and anoikis [12].
Fu et al., "Elevated autocrine EDIL3 protects hepatocellular carcinoma from anoikis through RGD-mediated integrin activation," Molecular Cancer, vol.