anoikis


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anoikis

A type of programmed cell death (apoptosis) that is induced by a loss of correct cell/extracellular matrix attachment. Cells require intact integrin family receptors to suppress anoikis, and the process requires mitochondrial membrane permeabilisation; certain cells (e.g., epithelial and endothelial cells) are more resistant to anoikis.

Anoikis resistance can be induced through activation of extracellular signalling-receptor kinase (ERK) and the phosphatidylinositol 3-kinase (PI3K) signalling cascade by hepatocyte growth factor (HGF). Metastatic cells are resistant to anoikis and often have increased levels of the death receptor-inhibiting protein FLIP.

anoikis

(a-ny'-kis) [ ¹an- + Gr. oikia, house + -(s)is]
Programmed cell death occurring in epithelial cells. It is associated with loss of the normal ability to establish contacts between the cell and the extracellular matrix.
See: apoptosis

anoikis

a special form of APOPTOSIS, whereby cells undergo cell death after disruption of cell-matrix interactions. Anoikis ensures that cells are unable to survive in inappropriate locations. It occurs when epithelial cells (see EPITHELIUM are either not bound to the matrix via INTEGRINS or are bound via the wrong integrins. The process is also called detachment-induced cell death or suspension-induced apoptosis.
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In fact, there are several primary contributors in the emergence of androgen-independent metastatic prostate cancer such as activation of survival pathways, including apoptosis, suppression of anoikis resistance, (13) and increased neovascularization.
Loss of expression of tropomyosin-1, a novel class II tumor suppressor that induces anoikis, in primary breast tumors.
00 Bluecoat Story Night The Bluecoat, School Lane, 0151 702 5324, to Fri 18 Nov MUSIC Mogwai Camp and Furnace, 67 Greenland Street, 0151 708 2890, Mon 24 Oct Anoikis: Howling Into the Sun Anoikis is dancer and choreographer Melissa Pasut and electroacoustic composer/ filmmaker Andrew Leslie Hooker, who on this occasion is joined by collaborative artist Rachel Sweeney (dancer/ choreographer) Capstone Theatre, Shaw St, 0844 800 0410, Mon 24 Oct, PS10.
In a 2004 publication, Higuchi and Jass (11) updated these concepts, stating: "Using more modern terminology, the hyperplastic polyp can be defined as a lesion caused by the inhibition of programmed cell death or apoptosis," which they explain is probably a special form of apoptosis called anoikis that is associated with programmed exfoliation of surface epithelial cells.
Furthermore, EUG induces alteration on cellular architecture probably by perturb cytoskeleton dynamics leading to a cytoplasmic retraction, shrinkage, pyknosis and cell detachment culminating in anoikis, especially in MCF-7, SiHA and SK-MEL-28 cells.
The presence of CTM supports the speculation that cells within CTM have a survival advantage via protection from anoikis (24-26).
Polyphenon E, a standardized green tea extract, induces endoplasmic reticulum stress, leading to death of immortalized PNT1a cells by anoikis and tumorigenic P[C.
It has been reported that SIRT1 increases cell invasion, anoikis resistance, and EMT of GC cells [21].
Ebola virus glycoprotein-mediated anoikis of primary human cardiac microvascular endothelial cells.
DOC-2/hDab-2 inhibits ILK activity and induces anoikis in breast cancer cells through an Akt-independent pathway.
Walden PD, Globina Y, Nieder A (2004) Induction of anoikis by doxazosin in prostate cancer cells is associated with activation of caspase-3 and a reduction of focal adhesion kinase.