ANO1

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ANO1

A gene on chromosome 11q13.2 that encodes anoctamin 1, a protein which is thought to act as a calcium-activated chloride channel; it is highly expressed in liver and skeletal muscle and is required for normal tracheal development.
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This is mediated by active ion transport, for instance by the cystic fibrosis transmembrane conductance regulator protein or calcium-activated chloride channels such as anoctamin-1 (ANO-1/TMEM16A).[38],[39] Chloride secretion and reabsorption of sodium by the epithelial sodium channel have been shown to regulate ASL volume.[40] This has important consequences for mucociliary clearance as it determines the hydration state of the mucus gel, as well as the height of the periciliary layer which is an important determinant of ciliary movement.[41] Moreover, transport of bicarbonate regulates the pH of the ASL,[42] which may affect the activity of pH-sensitive AMPs and mucus viscosity.[43],[44]{Figure 3}
Airway Epithelial Cell Function and Respiratory Host Defense in Chronic Obstructive Pulmonary Disease
DOG1 is also known as Anoctamin-1 (Ano-1), transmembrane protein 16A (TMEM16A), overexpressed in oral (squamous cell) carcinoma 2 (ORAOV2), and tumor-amplified and overexpressed sequence 1 (TAOS1).
An Update on the Application of Newly Described Immunohistochemical Markers in Soft Tissue Pathology
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