Annexins are a family of intracellular proteins that bind to phosphatidylserine (PS).
To examine whether apoptosis was induced by Dec 602 in the 10-[micro]g/kg body weight group, splenocytes were stained with the apoptosis markers Annexin V and 7-ADD and sorted by FACS (Figure 4A).
As part of this process, phosphatidylserine is translocated from the inner (cytoplasmic) leaflet of the plasma membrane to the outer (cell surface) leaflet soon after the induction of apoptosis ("flippage"), where proteins such as the annexins are known to bind with high affinity .
The annexins are a structurally related family of [Ca.
An immune response manifested by the common occurrence of annexins I and II autoantibodies and high circulating levels of IL-6 in lung cancer.
The treatment with eurycomanone reduced the abundance expression of the lung cancer markers, heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1, p53 tumor suppressor protein and other cancer-associated genes including prohibitin (PHB), annexin 1 (ANX1) and endoplasmic reticulum protein 28 (ERp28) but not the house keeping genes.
1]-antitrypsin, 2%); annexins
, 1%; and complement factors, 1%.
Cellular processes : Annexins
are the family of calcium-dependent phospholipid binding proteins.
constitute a class of Cat+- binding proteins that interact with phospholipid membranes in a Cat+-dependent manner (Burgoyne and Geisow 1989).
A1 is a member of the annexins
belong to a family of the calcium-dependent phospholipid binding proteins and are substrates of receptor tyrosine kinases.
Circulating Gc-globulin colocalizes with both CD44 and annexin
A2 receptors on the cell surface and may use both pathways to enhance C5a-mediated chemotaxis (33).