ANXA1

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ANXA1

A gene on chromosome 9q21.13 that encodes annexin 1, a calcium/phospholipid-binding protein that promotes membrane fusion and is involved in exocytosis. Annexin 1 regulates phospholipase A2 activity and thus may have anti-inflammatory activity.
References in periodicals archive ?
Lim, "Annexin-1 regulates growth arrest induced by high levels of estrogen in MCF-7 breast cancer cells," Molecular Cancer Research, vol.
Wallace, "Annexin-1 modulates repair of gastric mucosal injury," American Journal of Physiology, vol.
Schuliga et al., "Annexin-1 signals mitogen-stimulated breast tumor cell proliferation by activation of the formyl peptide receptors (FPRs) 1 and 2," The FASEB Journal, vol.
DeStefani et al., "Annexin-1 and peptide derivatives are released by apoptotic cells and stimulate phagocytosis of apoptotic neutrophils by macrophages," Journal of Immunology, vol.
Annexin-1 downregulation is associated with clinical outcome in Chinese patients with hilar cholangiocarcinoma.
Baek, "Annexin-1 regulated by HAUSP is essential for UV-induced damage response," Cell Death & Disease, vol.
However, the addition of annexin-1 (a glucocorticoid-induced anti-inflammatory protein) to the growing family of ALX ligands has provided evidence that this receptor can also modulate anti-inflammatory signaling [13] viaproteins.
Uteroglobin (UG), a steroid-inducible, 16 kDa secreted protein with potent anti-inflammatory/immunomodulatory activities, was found to share short peptide sequence similarities with annexin-1, termed the antiflammin motif [14-17].
Like annexin-1, UG is also known as a secretory, glucocorticoid-inducible protein [17], while displaying powerful immunomodulatory properties, similar to those of [LXA.sub.4], such as inhibition of IL-6 release [30], reduction of cellular infiltrates in the airways [31], decreased synthesis of prostaglandins (namely, PGF2 and PGE2 [32]), and reduced lysophosphatidic acid plasma levels [33].