ANXA1

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ANXA1

A gene on chromosome 9q21.13 that encodes annexin 1, a calcium/phospholipid-binding protein that promotes membrane fusion and is involved in exocytosis. Annexin 1 regulates phospholipase A2 activity and thus may have anti-inflammatory activity.
References in periodicals archive ?
Lim, "Annexin-1 regulates growth arrest induced by high levels of estrogen in MCF-7 breast cancer cells," Molecular Cancer Research, vol.
Functional Interactions between [BK.sub.Ca] [alpha]-Subunit and Annexin A5: Implications in Apoptosis
Wallace, "Annexin-1 modulates repair of gastric mucosal injury," American Journal of Physiology, vol.
Schuliga et al., "Annexin-1 signals mitogen-stimulated breast tumor cell proliferation by activation of the formyl peptide receptors (FPRs) 1 and 2," The FASEB Journal, vol.
Deregulation of annexin-A1 and galectin-1 expression in precancerous gastric lesions: intestinal metaplasia and gastric ulcer
DeStefani et al., "Annexin-1 and peptide derivatives are released by apoptotic cells and stimulate phagocytosis of apoptotic neutrophils by macrophages," Journal of Immunology, vol.
Urine annexin A1 as an index for glomerular injury in patients
Annexin-1 downregulation is associated with clinical outcome in Chinese patients with hilar cholangiocarcinoma.
Inhibitory effects of curcumin on gastric cancer cells: a proteomic study of molecular targets
Baek, "Annexin-1 regulated by HAUSP is essential for UV-induced damage response," Cell Death & Disease, vol.
The Antiapoptosis Effect of Glycyrrhizate on HepG2 Cells Induced by Hydrogen Peroxide
However, the addition of annexin-1 (a glucocorticoid-induced anti-inflammatory protein) to the growing family of ALX ligands has provided evidence that this receptor can also modulate anti-inflammatory signaling [13] viaproteins.
Uteroglobin (UG), a steroid-inducible, 16 kDa secreted protein with potent anti-inflammatory/immunomodulatory activities, was found to share short peptide sequence similarities with annexin-1, termed the antiflammin motif [14-17].
Like annexin-1, UG is also known as a secretory, glucocorticoid-inducible protein [17], while displaying powerful immunomodulatory properties, similar to those of [LXA.sub.4], such as inhibition of IL-6 release [30], reduction of cellular infiltrates in the airways [31], decreased synthesis of prostaglandins (namely, PGF2 and PGE2 [32]), and reduced lysophosphatidic acid plasma levels [33].
Uteroglobin, a possible ligand of the lipoxin receptor inhibits serum amyloid A-driven inflammation
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