annexin


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annexin

A generic term for a large (160 +) family of calcium- and phospholipid-binding proteins and phospholipase A2- and blood coagulation inhibitors, which interact with acidic membrane phospholipids in cell membranes.

annexin

One of a family of over 20 proteins first described in 1990, that include vascular anticoagulant proteins, placental proteins, placental anticoagulant proteins, lipocortins and endonexins. Annexins have similar structures, usually with four domains of 70 amino acids, and all are capable of binding calcium and phospholipids. They are present in a wide variety of cell types. Annexin II acts to bind plasminogen and TISSUE PLASMINOGEN ACTIVATOR to the endothelial cell surface. Annexin V forms an antithrombotic shield around procoagulant phospholipids.
References in periodicals archive ?
Tenders are invited for Annexin V Apoptosis Detection Kit
5), late-stage apoptotic cells are double positive for annexin V and PI (Annexin V+PI+) and distributed in the right upper quadrant (RU), normal viable cells are double negative for Annexin V and PI (Annexin V-PI-) and distributed in the left lower quadrant (LL), and early-stage apoptotic cells are Annexin V-positive and PI-negative (Annexin V+PI-), and are distributed in the right lower quadrant.
Apoptosis cells were evaluated using annexin V/PI by flow cytometry.
OSCC cells were stained with Annexin V and propidium iodide (PI) according to the manufacturer's manual (Annexin-V/PI Apoptosis Kit, BD Biosciences).
Fetus bovine serum (FBS) was from GIBCO (USA) and Annexin V-FITC/PI apoptosis kit from BD (USA).
Thus, Annexin V single positive represents the early apoptotic stage of cells, and Annexin V/7-ADD double positive indicates the late stage of apoptosis.
Tabas attaches nanoparticles developed by Omid Farokhzad of Harvard University to a small section of a protein called annexin Al.
The effects of selenite on HCT116 and SW480 cell apoptosis were investigated with an Annexin V/propidium iodide (PI) double staining kit by flow cytometry.
Induction of apoptosis by high dose of GNPs in HeLa cells was assessed by MTT assay, Acridin orange, DAPI staining, Annexin V/PI double-labeling flow cytometry and caspase activity assay.
Apoptotic cells were detected by fluorescence-activated cell sorting (FACS) with the FITC Annexin V Apoptosis Detection Kit I (eBiosciences, San Diego, CA, USA).
Cell apoptosis was determined using the annexin V-FITC apoptosis detection kit (Bioscience, Beijing, China).