Two SNPs were located on a narrow region of chromosome 4 (from 15.59 Mb to 16.04 Mb), and the nearest genes were inhibitor of apoptosis protein 3 (IAP3) and sosondowah ankyrin repeat
domain family member D (SOWAHD).
However, it was proven that the SNP rs1800497 is a part of the exon 8 of ankyrin repeat
and protein kinase domain-containing protein 1 (ANKK1) gene .
Several scaffolds, such as affibody molecules, knottins, designed ankyrin repeat
proteins (DARPins), adnectins, and ADAPTs, have been preclinically evaluated for radionuclide molecular imaging and demonstrated capacity of imaging molecular targets in vivo at the day of injection .
Background: The Notch-regulated ankyrin repeat
protein (NRARP) is recently found to promote proliferation of breast cancer cells.
The active ingredient, which comprises several DARPins (designed ankyrin repeat
proteins), is also easy to produce.
The Z-disk proteins include [alpha]-actinin 2, cardiac ankyrin repeat
protein, muscle LIM protein, LIM binding domain 3, myozenin 2, telethonin, and vinculin/metavinculin.
The drug MP0112 is a designated ankyrin repeat
protein that selectively binds VEGF-A isoforms.
"Conformation-dependent recognition of HIV gp120 by designed ankyrin repeat
proteins provides access to novel HIV entry inhibitors," Journal of Virology 87(10): 5868-5881.
The Coxiella burnetii ankyrin repeat
domain-containing protein family is heterogeneous.
Biopharmaceutical company Cubist Pharmaceuticals Inc (NASDAQ:CBST) and Hydra Biosciences Inc announced on Tuesday the joint proposal to commence a Phase 1 clinical study for a small molecule antagonist of the human Transient Receptor Potential Ankyrin repeat
1 (TRPA1) ion channel.
EPH receptor A5, RAB17, SH3 and multiple ankyrin repeat
domains 2, and GHRL are related to regulation of synapse assembly [32-34].