ankyrin


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an·ky·rin

(ang'ki-rin),
An erythrocyte membranal protein that binds spectrin. A deficiency in ankyrin may lead to a type of hereditary spherocytosis.
See also: nexins.
Synonym(s): anchorin, syndein
[G. ankyra, anchor, + -in]

ankyrin

Any of a family of proteins which mediate the binding of integral membrane proteins to the cytoskeleton, e.g., spectrin to the erythrocyte’s anion exchange (band-III) protein.

ankyrin

(ang′kĭ-rin)
A structural protein in red blood cells that binds cell membrane transport molecules to spectrin.
References in periodicals archive ?
Upregulation of the Transient Receptor Potential Ankyrin 1 Ion Channel in the Inflamed Human and Mouse Colon and Its Protective Roles.
Rh-associated glycoprotein (RhAG) BGAs complex with Rh proteins (RhD, RhCE) in the red cell membrane ankyrin complex, and associate with glycophorin A and B (GPA, GPB), Landsteiner-Wiener (LW; ICAM-4) glycoprotein, and ultimately Band 3.
They consist of a lipid bilayer, globular proteins, and a spectrin matrix, connected with a lipid bilayer by protein complexes of band 3, band 4.1, actin, and ankyrin. The property of the composite structures is their ability to acquire new mechanical properties when changing external conditions.
Several scaffolds, such as affibody molecules, knottins, designed ankyrin repeat proteins (DARPins), adnectins, and ADAPTs, have been preclinically evaluated for radionuclide molecular imaging and demonstrated capacity of imaging molecular targets in vivo at the day of injection [14].
The Bd0816 and Bd3459 encode D-alanyl-D-alanine carboxypeptidase usually expressed at the point of prey entry while Bd3460 encodes a protein called ankyrin which protects Bdellovibrio hydrolytic enzymes which it secretes during prey invasion.
Kaneko, "Roles of transient receptor potential ankyrin 1 in oxaliplatin-induced peripheral neuropathy," Biological and Pharmaceutical Bulletin, vol.
Yamamoto, "Epithelial transient receptor potential ankyrin 1 (TRPA1)-dependent adrenomedullin upregulates blood flow in rat small intestine," American Journal of Physiology-Gastrointestinal and Liver Physiology, vol.
Abbreviations Dll4: Delta-like ligand 4 DR: Diabetic retinopathy Fc: Constant Fc region of human IgG GS lectin: Griffonia simplicifolia lectin I Nrarp: Notch-regulated ankyrin repeat protein OIR: Oxygen-induced retinopathy VEGF-A: Vascular endothelial growth factor A wet AMD: Wet form of age-related macular degeneration WT: Wild type.
Metzler et al., "HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis," Human Molecular Genetics, vol.
Gene name Gene Conserved 8-mer 7-mer symbol sites Chemokine Z (C-X-C motif) CXC 12 1 1 ligand 12 NOTCH-regulated ankyrin NRARP 1 1 repeat protein Astrotactin-1 ASTN1 1 1 Nasal embryonic LHRH NELF 1 1 factor K(Lysine) acetyl KAT6B 1 1 transferase 6B Protein kinase C, alpha PRKCA 1 1 EF-hand domain family, EFHD2 1 1 member D2 Mitogen-activated protein MAP2K4 1 1 kinase kinase 4 Zinc finger protein 219 ZNF219 1 1 Ring finger protein 165 RNF165 1 1 Protocadherin 7 PCDH7 1 1 EPH receptor A3 EPHA3 1 1 Insulin receptor IRS1 1 1 substrate 1 POU class 2 homeobox 1 POU2F1 1 1
fam A FC=0.46 [check] FCRLA Fc receptor-like A -1.074 FC=0.74 [check] POU2AF1 POU class 2 -1.042 associating factor 1 FC=0.48 BANK1 B-cell scaffold protein -1.039 with ankyrin repeats 1 FC=0.61 [check] IGHM immunoglobulin heavy -0.999 constant mu FC=0.39 BACH2 BTB and CNC homology 1, -0.989 basic leucine zipper 2 FC=0.5 transcription factor TCL1A T-cell leukemia/ -0.977 lymphoma 1A FC=0.53 LINC00926 long intergenic non-protein -0.957 coding RNA 926 FC=0.51 [check] PAX5 paired box 5 -0.952 FC=0.51 [check] CCR7 chemokine (C-C motif) -0.856 receptor 7 FC=0.55 * S V = is a gene found in a previous study/publication (Caucasian study, Saligan et al., 2013) N=20