ankyrin


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an·ky·rin

(ang'ki-rin),
An erythrocyte membranal protein that binds spectrin. A deficiency in ankyrin may lead to a type of hereditary spherocytosis.
See also: nexins.
Synonym(s): anchorin, syndein
[G. ankyra, anchor, + -in]

ankyrin

/an·ky·rin/ (ang´kĭ-rin) a membrane protein of erythrocytes and brain that anchors spectrin to the plasma membrane at the sites of ion channels.

ankyrin

Any of a family of proteins which mediate the binding of integral membrane proteins to the cytoskeleton, e.g., spectrin to the erythrocyte’s anion exchange (band-III) protein.

ankyrin

(ang′kĭ-rin)
A structural protein in red blood cells that binds cell membrane transport molecules to spectrin.
References in periodicals archive ?
The ankyrin repeat as molecular architecture for protein recognition.
a, b) Transient receptor potential ankyrin 1 in synovial tissues of normal and knee osteoarthritis groups detected by indirect immunofluorescence.
33) Marker Base pair Mapped close identity to gene (%) AFLP1 223/223 (100) CYP24A1, D0K5 AFLP2 71/71 (100) ANKRD16 AFLP3 167/169 (99) RREB1 AFLP7 63/79 (90) 0R51V1 AFLP10 171/171 (100) GUCY1B3 AFLP, amplified fragment length polymorphism; ANKRD16, ankyrin repeat domain 15; CYP24A1, cytochrome P4B0 family 24 subfamily A member 1; D0K5, docking protein 5; GUCY1B3, guanylate cyclase 1 soluble beta 3; 0R51V1, olfactory receptor family 51, subfamily V, member 1; RREB1, ras responsive element binding protein 1.
In a one-year re-integration phase I will perform follow-up mechanistic structural studies in the Olga Mayans lab (University of Liverpool) to determine the structural basis how the CARP (cardiac ankyrin repeat protein)-titin signaling axis mediates cardiomyocyte protection, and in the Labeit lab (University of Heidelberg, Medical Faculty Mannheim) how to perturb activity of this complex by small molecules.
NAPQI (N-acetyl-p-benzoquinone imine) which acts on transient receptor potential ankyrin (TRAPAI) receptors in spinal cord to alleviate pain.
the membrane protein [beta]-dystroglycan [38, 39] and to several other proteins such as plectin [40], ankyrin [41] and the intermediate filament protein synemin [25].
The Z-disk proteins include [alpha]-actinin 2, cardiac ankyrin repeat protein, muscle LIM protein, LIM binding domain 3, myozenin 2, telethonin, and vinculin/metavinculin.
The presence of 6 conserved ankyrin repeats in SgI[kappa]B and its close phylogenetic relationship with other I[kappa]Bs strongly suggest that SgI[kappa]B belongs to the I[kappa]B superfamily.
4] Ankyrin G (ANKG), which is encoded by the ANK3 gene, is crucial for the stability of the neuronal membrane [5, 6] and facilitates the connection between axons and ribbon synapses.
Conformation-dependent recognition of HIV gp120 by designed ankyrin repeat proteins provides access to novel HIV entry inhibitors," Journal of Virology 87(10): 5868-5881.