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When bones of a joint are fused, stiff, or rigid.


caused by or emanating from fixation of the joint.

ankylosing spondylitis
ankylosing spondylosis

Patient discussion about ankylosing

Q. Is ankylosing spondylitis genetically inherited?

A. It is known today that ankylosing spondylitis (spondyloarthritis) has a very strong genetic connection. It is not a disease inhertited by a single gene that is dominant, but certainly there is genetic predisposition in families (and a more detailed information- about 90% of the patients express the HLA-B27 genotype).

Q. I have had ankylosing spondilitis for over 25 years. What is available at this point to mitigate the effects?

A. The mainstay of the treatment severe ankylosing spondylitis today are "anti-TNF", drugs that affect the immune system through blocking the action of a protein called TNF.

Other optional treatments include sulfasalazine and thalidomide.
Of course, all these treatments require prescription and consultation with a doctor (in this case usually rheumatologist).

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More discussions about ankylosing
References in periodicals archive ?
The use of NSAIDs--a guideline-recommended first-line therapy in ankylosing spondylitis--trended lower over time, albeit not significantly so.
Ankylosing spondylitis patients with the three most common MEFV mutations (M694V, E148Q and V726A, respectively) were separately compared with the non-MEFV mutation group with regard to age of onset of symptoms, peripheral joint involvement, number of involved joints, hip joint involvement, and current treatments (Table 6).
What intrinsic and extrinsic factors affect the development of anti-drug antibody to innovator infliximab and its biosimilar CT-P13 in rheumatoid arthritis and ankylosing spondylitis.
The efficacy of HUMIRA in the treatment of ankylosing spondylitis was evaluated by the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and global improvement.
Spinal radiographic changes in ankylosing spondylitis: association with clinical characteristics and functional outcome.
Six-month results of a double- blind, placebo-controlled trial of etanercept treatment in patients with active ankylosing spondylitis.
The sternoclavicular joint is more often involved in ankylosing spondylitis, degenerative arthritic conditions (i.
Co-marketed by Amgen and Wyeth, the injectable drug will now be used to treat ankylosing spondylitis.
Biologist Peter Parham at Stanford University calls the report a "landmark" that may help scientists uncover the mechanism causing these inflammatory diseases -- which include, among others, ankylosing spondylitis (fusion of spinal bones), an arthritis associated with the skin disorder psoriasis, and an arthritis accompanied by bowel inflammation.
com/research/j7kg94/how_will_new) has announced the addition of Decision Resources, Inc's new report "How Will New Entrants Alter the Biologics Landscape in Ankylosing Spondylitis and Psoriatic Arthritis?
104 Week sub-analysis data from the Cosentyx Phase III Measure 1 study in patients with ankylosing spondylitis (AS) presented at ACR 2015(1,2)