anistreplase


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anistreplase

 [an″is-trep´lās]
a thrombolytic agent primarily used to clear coronary vessel occlusions associated with myocardial infarction; administered intravenously.

anistreplase

/an·is·trep·lase/ (an″is-trep´lās) a thrombolytic agent used to clear coronary vessel occlusions associated with myocardial infarction.

anistreplase

a plasminogen activator.
indication This drug is used in acute MI for lysis of coronary artery thrombi.
contraindications Known hypersensitivity to this drug or streptokinase; active internal bleeding; intraspinal or intracranial surgery; central nervous system neoplasms; severe, uncontrolled hypertension; cerebral embolism; thrombosis; hemorrhage; recent trauma; or history of cerebrovascular accident all prohibit the use of this drug.
adverse effects Adverse effects of this drug include headache, fever, sweating, agitation, dizziness, paresthesia, tremor, vertigo, hypotension, conduction disorders, nausea, vomiting, decreased hematocrit, surface bleeding, rash, urticaria, phlebitis at the injection site, itching, flushing, low back pain, arthralgia, altered respirations, and dyspnea. Life-threatening side effects include intracranial hemorrhage, dysrhythmias, GI bleeding, genitourinary bleeding, intracranial bleeding, retroperitoneal bleeding, thrombocytopenia, bronchospasm, lung edema, and anaphylaxis.

anistreplase

See APSAC.

anistreplase

A clot-dissolving drug used to try to re-establish blood flow in the heart muscle in the early treatment of heart attacks. A brand name is Eminase.
References in periodicals archive ?
Quantification of the benefit of earlier thrombolytic therapy: Five-year results of the Grampian Region Early Anistreplase Trial (GREAT).
The GREAT trial showed a substantially lower mortality at 1 year among patients randomized to prehospital anistreplase (APSAC) at 10.
The three agents in this category are anistreplase (Eminase) and streptokinase (Streptase), both rated C, and urokinase (Abbokinase).
No human pregnancy data are available for anistreplase.
Four other plasminogen activators remain available in the USA: streptokinase, anistreplase, retavase, and alteplase.
The view now is that the effectiveness of anistreplase is half that of what was originally claimed.
GREAT (Grampian Region Early Anistreplase Trial) calismasi nda hastane oncesi trombolitik tedavi hastane icindeki uygulamasi ile karsilastirildi (37).
anistreplase and of aspirin plus heparin vs aspirin alone among 41,299 cases of suspected acute myocardial infarction.