Anisocytosis and anisokaryosis
were moderate; occasional fine pink extravascular material was associated with cell aggregates.
Hashimoto Thyroiditis: TIC Smear Shows Syncytial Cluster of Hurthle Cells Showing Abundant Cytoplasm with Anisokaryosis
H&E x 400
There was moderate anisocytosis and anisokaryosis
. Mitotic figures were not observed (Figure 1B).
Nuclear alterations (anisokaryosis
, anisocytosis, and karyomegaly) were described.
The Giemsa stained impression smears revealed characteristic round cells exhibiting features like anisocytosis, anisokaryosis
, hyperchromatic nucleus, basophilic cytoplasm and increased nuclear to cytoplasmic ratio along with multiple vacuoles in cytoplasm (Fig.
There was mild anisocytosis, mild anisokaryosis
, and a low mitotic count (1 mitotic figure per 10 consecutive high power fields, 400x).
Aspiration cytology of the subcutaneous nodules showed marked anisokaryosis
, hyperchromatic and stippled nuclei, prominent nucleoli, intranuclear inclusions, and pigment laden melanophages (Figure 2a).
Follicular cells were seen as round mild pleomorphic cells with scanty cytoplasm and mild nuclear anisokaryosis
. Aspirate from papillary carcinomas showed papillary sheets of monomorphic cells with moderate pale pink cytoplasm, large round uniform nucleus with prominent small basophilic nucleolus and some nuclei with inclusions.25
There is an increase in the number of mitoses, and dyskaryosis, anisokaryosis
, and dyschromatosis are present (figure 3).
The characteristic cytologic features of conventional melanoma are: high cell-yield, predominant epithelioid/plasmacytoid cells with eccentrically placed nuclei and a dissociated pattern, abundant cytoplasm, cytoplasmic melanin pigments, prominent anisokaryosis
, macronucleoli, intra-nuclear cytoplasmic inclusions, and variable numbers of bi- and multinucleated cells.
These abnormalities included marked binucleation, anisokaryosis
, karyolysis, karyorrhexis and karyopyknosis.
Hepatocytes with discreet anisokaryosis
, formation of chromocenters and nucleoli, and focal intrahepatocyte cholestasis (HE, 600x) were found in the liver of both the IO-NPs (0.7 mL/kg) treated and control groups (Figure 5(a)) with no significant difference between them.