Moderate anisocytosis and anisokaryosis
were present, and 3 mitotic figures were seen in ten X400 fields.
Mild anisocytosis, anisokaryosis
, and rare mitosis were observed.
Aspiration cytology of the subcutaneous nodules showed marked anisokaryosis
, hyperchromatic and stippled nuclei, prominent nucleoli, intranuclear inclusions, and pigment laden melanophages (Figure 2a).
Follicular cells were seen as round mild pleomorphic cells with scanty cytoplasm and mild nuclear anisokaryosis
Cytology was characterized by presence of large number of pleiomorphic fibroblasts with anisocytosis, anisokaryosis
, prominent nucleoli and mitotic figures (Fig.
Little chromatin was found, identifying one or two nucleoli per cell; further observations included: anisokaryosis
, anisocytosis, high pleomorphism and increased nucleus:cytoplasm ratio.
Nucleus showed moderate anisokaryosis
, granular chromatin & was centrally located with prominent nucleoli and intranuclear inclusion.
There is an increase in the number of mitoses, and dyskaryosis, anisokaryosis
, and dyschromatosis are present (figure 3).
The characteristic cytologic features of conventional melanoma are: high cell-yield, predominant epithelioid/plasmacytoid cells with eccentrically placed nuclei and a dissociated pattern, abundant cytoplasm, cytoplasmic melanin pigments, prominent anisokaryosis
, macronucleoli, intra-nuclear cytoplasmic inclusions, and variable numbers of bi- and multinucleated cells.
These abnormalities included marked binucleation, anisokaryosis
, karyolysis, karyorrhexis and karyopyknosis.
The nuclei were predominantly round to oval, with irregular contours, showing finely aggregated chromatin pattern, indistinct nucleoli and moderate anisokaryosis
and pleomorphism (Figure 2).
Neoplastic cells were pleomorphic with marked anisocytosis and anisokaryosis