animal model


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Related to animal model: Mouse model, Model organism

an·i·mal mod·el

study in a population of laboratory animals that uses conditions in animals analogous to conditions of humans to simulate processes comparable with those that occur in human populations.

animal model

An animal that is an accidental or deliberate (though selective inbreeding) model of a human disease. Such models are experimental living systems that are used to study disease mechanisms and provide insight into possible therapies.

Animal models
• AIDS—SAIDS in macaque monkeys. 
• ALL—Immune deficient SCID mice. 
• Atherosclerosis—Watanabe rabbits. 
• Ceroid lipofuscinosis—Border collies.
• Charcot-Marie-Tooth disease type 1A—Pmp-22 mutant trembler-J mice.
• Congenital hyperbilirubinemia—Gunn rat enzymopathy.
• Congenital malignancy—Embryonal nephroma—pigs; hepatoblastoma—sheep; melanoma—darkly pigmented animals. 
• Crohn’s disease—Paratuberculosis/Johne’s disease, which affects dairy ruminants by Mycobacterium johnei.
• Cryptorchidism—dogs (castration).
• Cystinuria type I—Newfoundland dogs; Pebbles, a transgenic mouse model.
• Demyelination—Shiverer mouse.
• Diabetes insipidus—Brattleboro rats.
• Distichia—Cocker spaniels, dachshunds, bulldogs, Yorkshire terriers, poodles.
• End-organ resistance to normal hormones—Sebright bantam rooster.
• Endocardial fibrosis—Turkeys.
• Familial hypercholesterolaemia—Watanabe rabbits.
• Fibrosing alveolitis/Hamman-Rich disease—Bovine pulmonary disease. 
• GH-resistant dwarfism—Mini-mouse.
• Inherited giant platelet disorders—King Charles Spaniel dogs (Cavaliers).
• Kinky hair disease—Copper deficiency in sheep.
• Klinefelter syndrome—X-linked testicular feminisation in mice.
• Lymphocytic thyroiditis—Beagles, obese chickens, buffalo rats, primates.
• Lymphoma—Lymphosarcoma in dogs. 
• Malignant histiocytosis—Bernese Mountain dogs.
• Melanoma, spontaneously regressing—Sinclair swine.
• Mixed tumour (benign breast tumour)—Dogs.
• Muscular hypertrophy—Belgian blue cows.
• Myotonia congenita—Fainting goats.
• Neurolymphomatosis—Marek’s disease, induced by an oncogenic herpesvirus.
• Neuroplasticity—Aplysia, a marine mollusc.
• Osteopetrosis—Gray lethal mouse.
• Pacinian neurofibroma—Peking duck.
• Protothecosis—Collie dogs.
• Rheumatoid arthritis—Erysipelothrix-induced arthritis.
• Sleep apnea (obstructive)—English bulldog.
• Spermatocytic seminoma—old men and old dogs.
• Systemic lupus—NZB/NZW mice.
• Waardenburg syndrome—ferrets.

an·i·mal model

(an'i-măl mod'ĕl)
Study in a population of laboratory animals that uses conditions of animals analogous to conditions of humans to simulate processes comparable with those that occur in human populations.
References in periodicals archive ?
Choosing an animal model for the study of Huntington's disease.
All the 38(100%) subjects uniformly accepted the utility of simulation training in enhancing education, improving skill, and improving confidence by repeated practice, and felt that the inclusion of animal models for learning fundamental pleuroscopic procedures can help a lot in teaching.
On the other hand, animal models also have limitations.
Other animal models have been investigated for modeling periodontal diseases.
Procurement of animal models in recent past has not ushered in significant cost efficiencies from supply market.
Early biodistribution assessments can help in the choice of animal model and the duration of toxicology studies; using a small number of animals at continuous study intervals will develop a basic understanding of these endpoints.
The route of exposure to the challenge agent included in the animal model should be the same as the anticipated route of human exposure.
Various studies have been conducted with this animal model using ovalbumin (OVA), a well-known allergen in humans.
The company anticipates the availability of a small animal model could significantly reduce the time and money needed to develop novel drugs to treat the disease.
Task force chair Caroline Whitacre, PhD, is directing a large study of sex differences and disease severity and susceptibility in mice and rats with EAE (an animal model of MS).
[USPRwire, Mon Aug 26 2019] An animal on which certain pathological and biological experiments are carried out and tested, such animal is referred as an animal model. An animal model is used by virtue of its functional resemblance to the human body.
[ClickPress, Mon Aug 26 2019] An animal on which certain pathological and biological experiments are carried out and tested, such animal is referred as an animal model. An animal model is used by virtue of its functional resemblance to the human body.