This finding may pave the way for the detailed study of the neural substrates underlying other domain-specific anhedonias
and, from an evolutionary perspective, help us to understand how music acquired reward value.
On account of its ability to cause anhedonia
, dynorphin has been considered to be responsible for depression due to stress .
Some authors have demonstrated the specificity of anhedonia
in mood disorder compared to anxiety disorder  and compared to schizophrenia .
The baseline data suggest that passively collected "dry biomarkers" (digital assessments used to monitor for a treatment effect) correlate with specific symptom domains, including anhedonia
A recent magnetic resonance spectroscopy (MRS) study on unmedicated MDD patients revealed an interesting positive correlation between C-reactive protein (CRP) levels and the concentration of glutamate in the basal ganglia, which was associated with anhedonia
and psychomotor slowing (68).
Entre las dimensiones del CDI, la anhedonia
fue la que demostro correlaciones mas altas con la calidad de vida, relacion que fue confirmada en las regresiones lineales (tabla 4).
Highly distressed symptoms included feeling depressed / hopeless, feeling guilty, poor concentration, anhedonia
, initial insomnia, middle / terminal insomnia, and fatigue.
To test the predictive value of baseline measures of hedonic response to pleasant images, self-report anhedonia
, and future orientation on alcohol, marijuana, and NMPO use at follow-up, we conducted separate negative binomial regression models for alcohol and marijuana use (Atkins et al., 2013) and negative binomial hurdle regression model for NMPO use (Bandyopadhyay, DeSantis, Korte, & Brady, 2011).
Some depressed individuals suffer from motivational anhedonia
without experiencing a corresponding deficit in consummatory pleasure: they anticipate little or no enjoyment from various activities or experiences, but still enjoy them when they get them (Sherdell, Waugh and Gotlib (2012)).
Other common presenting features were anhedonia
(94.1%), anorexia (86.8%) and insomnia (84.9%).
An extreme amount of stress can lead to maladaptive behavioral changes such as anhedonia
and social avoidance, in rodents and humans, as well as serious health consequences by impacting on the nervous, endocrine, and immune systems.