angiotensinogen

angiotensinogen

 [an″je-o-ten´sin-o-jen]

a serum α₂-globulin secreted in the liver which, on hydrolysis by renin, gives rise to angiotensin.

an·gi·o·ten·sin·o·gen

(an'jē-ō-ten-sin'ō-jen),

The substrate for renin whereon through enzymatic action angiotensin I is liberated; an abundant α₂-globulin that circulates in the blood plasma.

Synonym(s): angiotensin precursor

angiotensinogen

A 60-kD, 1453-residue glycoprotein (13% carbohydrate) of the alpha2 globulin fraction of plasma proteins, which is synthesised and released from the liver and cleaved in the circulation to form the biologically inactive angiotensin I, a decapeptide split from the N-terminal by renin, a proteolytic enzyme.

A-I is in turn cleaved to form active A-II by ACE, which causes contraction of vascular smooth muscle and thus raises blood pressure and stimulates aldosterone release from the adrenal glands; A-III is then broken down by angiotensinases. The angiotensinogen gene is located on 1q42-43, and is mutated in essential hypertension.

angiotensinogen

Renin substrate A 60 kD glycoprotein of the α₂ globulin fraction of plasma proteins, which is synthesized and released from the liver, and cleaved in the circulation to form the biologically inactive, angiotensin I, a decapeptide split from the N-terminal by renin, a proteolytic enzyme. See Angiotensin, Renin-angiotensin system.

an·gi·o·ten·sin·o·gen

(an'jē-ō-ten-sin'ō-jen)

The substrate for renin from which through enzymatic action angiotensin I is liberated; an abundant α₂-globulin that circulates in the blood plasma.

angiotensinogen

an inactive precursor of ANGIOTENSIN; it is a large protein synthesized by the liver, secreted into the bloodstream and converted into angiotensin by RENIN.