angiotensinogen


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angiotensinogen

 [an″je-o-ten´sin-o-jen]
a serum α2-globulin secreted in the liver which, on hydrolysis by renin, gives rise to angiotensin.

an·gi·o·ten·sin·o·gen

(an'jē-ō-ten-sin'ō-jen),
The substrate for renin whereon through enzymatic action angiotensin I is liberated; an abundant α2-globulin that circulates in the blood plasma.

angiotensinogen

A 60-kD, 1453-residue glycoprotein (13% carbohydrate) of the alpha2 globulin fraction of plasma proteins, which is synthesised and released from the liver and cleaved in the circulation to form the biologically inactive angiotensin I, a decapeptide split from the N-terminal by renin, a proteolytic enzyme.

A-I is in turn cleaved to form active A-II by ACE, which causes contraction of vascular smooth muscle and thus raises blood pressure and stimulates aldosterone release from the adrenal glands; A-III is then broken down by angiotensinases. The angiotensinogen gene is located on 1q42-43, and is mutated in essential hypertension.

angiotensinogen

Renin substrate A 60 kD glycoprotein of the α2 globulin fraction of plasma proteins, which is synthesized and released from the liver, and cleaved in the circulation to form the biologically inactive, angiotensin I, a decapeptide split from the N-terminal by renin, a proteolytic enzyme. See Angiotensin, Renin-angiotensin system.

an·gi·o·ten·sin·o·gen

(an'jē-ō-ten-sin'ō-jen)
The substrate for renin from which through enzymatic action angiotensin I is liberated; an abundant α2-globulin that circulates in the blood plasma.

angiotensinogen

an inactive precursor of ANGIOTENSIN; it is a large protein synthesized by the liver, secreted into the bloodstream and converted into angiotensin by RENIN.
References in periodicals archive ?
Effect of bilateral nephrectomy on active renin, angiotensinogen, and renin glycoforms in plasma and myocardium.
Biomarkers Source cell Standard biomarkers Creatinine Muscle cells Albuminuria -- Potential biomarkers Cystatin C Nucleated cells/proximal tubular cells Neutrophil gelatinase- Neutrophils/distal associated lipocalin (NGAL) tubular cells Kidney injury molecule-1 Proximal tubular cells (KIM-1) Angiotensinogen Proximal tubular cells Periostin Bone/distal tubular cells Monocyte chemoattractant Macrophages, glomerular protein-1 (MCP-1) and tubular cells Biomarkers Description Standard biomarkers Glomerular filtration markers [8] Factors affecting creatinine generation (i) extremes of muscle mass, Creatinine (ii) extremes of body size, (iii) diet and nutritional status: high protein diet and creatine supplements, (iv) muscle wasting diseases.
Brand et al., "Suppression of angiogenesis, tumor growth, and metastasis by adenovirus-mediated gene transfer of human angiotensinogen," Molecular Therapy, vol.
(2009) Influence of angiotensinogen and angiotensin-converting enzyme polymorphisms on cardiac hypertrophy and improvement on maximal aerobic capacity caused by exercise training.
Kasper et al., "Baroreceptor reflex regulation in anesthetized transgenic rats with low glia-derived angiotensinogen," American Journal of Physiology--Heart and Circulatory Physiology, vol.
(G) AGT (angiotensinogen; left) and NPPC (natriuretic peptide type C; right) mRNA measured in transfected cells reated for 6 hr with Veh, E2, or Gen.
Effect of renal perfusion pressure on renal function, renin release and renin and angiotensinogen gene expression in rats.
This cascade of events is finally a potent stimulus for angiotensinogen expression and thereby contributes to increase the local synthesis of Ang II and the progression of hypertension and the establishment of renal injury.
We subsequently showed that ablation of PPAR[alpha] totally abolished hypertension and greatly reduced diet-induced atherosclerosis in the Tsukuba hypertensive mouse, a model of angiotensin II (AII-) mediated hypertension and atherosclerosis due to the transgenic expression of the human renin and angiotensinogen genes.
Studies suggest that both hyperglycemia and hyperinsulinemia activate the Renin angiotensin system (RAS) by increasing the expression of angiotensinogen, Angiotensin II (AT II), and the AT1 receptor, which, in concert, may contribute to the development of hypertension in patients with insulin resistance [87].
Among RAAS candidate genes, angiotensinogen (AGT), angiotensin II type I receptor (AGTR1), angiotensin-converting enzyme (ACE), and aldosterone synthase (CYP11B2) genes appear to be particularly relevant to renal disease [6].
Maxwell, "A molecular variant of angiotensinogen is associated with diabetic nephropathy in IDDM," Diabetes, vol.

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