angiotensinogen


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angiotensinogen

 [an″je-o-ten´sin-o-jen]
a serum α2-globulin secreted in the liver which, on hydrolysis by renin, gives rise to angiotensin.

an·gi·o·ten·sin·o·gen

(an'jē-ō-ten-sin'ō-jen),
The substrate for renin whereon through enzymatic action angiotensin I is liberated; an abundant α2-globulin that circulates in the blood plasma.

angiotensinogen

/an·gio·ten·sin·o·gen/ (-ten-sin´o-jen) a serum α2-globulin secreted in the liver which, on hydrolysis by renin, gives rise to angiotensin.

angiotensinogen

[-tensin′əjən]
a serum glycoprotein produced in the liver that is the precursor of angiotensin.

angiotensinogen

A 60-kD, 1453-residue glycoprotein (13% carbohydrate) of the alpha2 globulin fraction of plasma proteins, which is synthesised and released from the liver and cleaved in the circulation to form the biologically inactive angiotensin I, a decapeptide split from the N-terminal by renin, a proteolytic enzyme.

A-I is in turn cleaved to form active A-II by ACE, which causes contraction of vascular smooth muscle and thus raises blood pressure and stimulates aldosterone release from the adrenal glands; A-III is then broken down by angiotensinases. The angiotensinogen gene is located on 1q42-43, and is mutated in essential hypertension.

angiotensinogen

Renin substrate A 60 kD glycoprotein of the α2 globulin fraction of plasma proteins, which is synthesized and released from the liver, and cleaved in the circulation to form the biologically inactive, angiotensin I, a decapeptide split from the N-terminal by renin, a proteolytic enzyme. See Angiotensin, Renin-angiotensin system.

an·gi·o·ten·sin·o·gen

(an'jē-ō-ten-sin'ō-jen)
The substrate for renin from which through enzymatic action angiotensin I is liberated; an abundant α2-globulin that circulates in the blood plasma.

angiotensinogen

an inactive precursor of ANGIOTENSIN; it is a large protein synthesized by the liver, secreted into the bloodstream and converted into angiotensin by RENIN.

angiotensinogen

a serum α2-globulin secreted in the liver which, on hydrolysis by renin, gives rise to angiotensin.
References in periodicals archive ?
1999) Angiotensinogen gene M235T polymorphism predicts left ventricular hypertrophy in endurance athletes.
ACE, angiotensinogen and obesity: a potential pathway leading to hypertension.
A redox switch in angiotensinogen modulates angiotensin release.
Association of angiotensinogen gene polymorphisms with essential hypertension in African-Americans and Caucasians.
Women with pre-eclampsia were found to have more oxidised, and hence active, angiotensinogen than women without the condition.
40) Angiotensinogen and ACE (angiotensin converting enzyme) are also secreted by adipocytes and promote hypertension, another characteristic of MSX.
The M235T polymorphism of the angiotensinogen gene in women with polycystic ovary syndrome.
Another study of ten polymorphisms in nine genes found a strong association between a specific angiotensinogen haplotype and genetic susceptibility to PE (14).
Adipocytes produce substances such as angiotensinogen, interleukin-6, tumor necrosis factor alpha, C reactive protein, leptin, plasminogen activator factor 1 and adipokines.
Salt Lake City, UT) has patented methods and materials used to isolate and detect human diabetes mellitus predisposing gene, specifically the angiotensinogen (AGT) gene, some mutant alleles of which cause susceptibility to insulin-dependent diabetes mellitus (IDDM).
Renin cleaves an inactive peptide called angiotensinogen, converting it into angiotensin I, which travels in the circulation to the lung capillaries where it is converted to angiotensin II (AII).
Although hundreds of genes differed between the control- and alcohol-fed rats, the authors noted with interest that the expression of angiotensinogen and angiotensin converting enzyme (ACE), which are key components of the renin-angiotensin system,?

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