angiotensinogen


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angiotensinogen

 [an″je-o-ten´sin-o-jen]
a serum α2-globulin secreted in the liver which, on hydrolysis by renin, gives rise to angiotensin.

an·gi·o·ten·sin·o·gen

(an'jē-ō-ten-sin'ō-jen),
The substrate for renin whereon through enzymatic action angiotensin I is liberated; an abundant α2-globulin that circulates in the blood plasma.

angiotensinogen

/an·gio·ten·sin·o·gen/ (-ten-sin´o-jen) a serum α2-globulin secreted in the liver which, on hydrolysis by renin, gives rise to angiotensin.

angiotensinogen

[-tensin′əjən]
a serum glycoprotein produced in the liver that is the precursor of angiotensin.

angiotensinogen

A 60-kD, 1453-residue glycoprotein (13% carbohydrate) of the alpha2 globulin fraction of plasma proteins, which is synthesised and released from the liver and cleaved in the circulation to form the biologically inactive angiotensin I, a decapeptide split from the N-terminal by renin, a proteolytic enzyme.

A-I is in turn cleaved to form active A-II by ACE, which causes contraction of vascular smooth muscle and thus raises blood pressure and stimulates aldosterone release from the adrenal glands; A-III is then broken down by angiotensinases. The angiotensinogen gene is located on 1q42-43, and is mutated in essential hypertension.

angiotensinogen

Renin substrate A 60 kD glycoprotein of the α2 globulin fraction of plasma proteins, which is synthesized and released from the liver, and cleaved in the circulation to form the biologically inactive, angiotensin I, a decapeptide split from the N-terminal by renin, a proteolytic enzyme. See Angiotensin, Renin-angiotensin system.

an·gi·o·ten·sin·o·gen

(an'jē-ō-ten-sin'ō-jen)
The substrate for renin from which through enzymatic action angiotensin I is liberated; an abundant α2-globulin that circulates in the blood plasma.

angiotensinogen

an inactive precursor of ANGIOTENSIN; it is a large protein synthesized by the liver, secreted into the bloodstream and converted into angiotensin by RENIN.

angiotensinogen

a serum α2-globulin secreted in the liver which, on hydrolysis by renin, gives rise to angiotensin.
References in periodicals archive ?
When oxidative stress is present, the angiotensinogen molecule shifts its shape and floods the system with angiotensin
Women with pre-eclampsia were found to have more oxidised, and hence active, angiotensinogen than women without the condition.
Clinicians should also be aware that activity assays are also affected by conditions affecting angiotensinogen concentrations, such as pregnancy and estrogen administration.
Angiotensinogen gene haplotype and hypertension: interaction with ACE gene I allele.
SPP630 and SPP635, compounds with low nanomolar potency, have now been successfully tested in microdosing studies with human volunteers and in preclinical studies with transgenic rats that express the human genes for renin and angiotensinogen.
Second, proMBP is able to form a covalent complex with angiotensinogen (27, 28), and angiotensinogen thus potentially competes for proMBP, which may be relevant in conditions of pregnancy-induced hypertension and preeclampsia (27).
Testing in a rat model, that expresses the human genes for renin and angiotensinogen, has shown that the new series of renin inhibitors are both potent and orally effective, not only in reducing blood pressure but also in protecting the kidneys.
1]R (23), [alpha]-adducin (ADD) (24-26), G-protein [beta]3 subunit (GNB3) (27), CYP11B2 (aldosterone synthase) (28), angiotensin-converting enzyme (ACE) (26, 29), angiotensinogen (AGT) (21, 25, 30), angiotensin II type 1 receptor ([AT.
Individuals with an inherited mutation in the angiotensinogen gene are far more likely to become hypertensive, experiencing a more severe form of the disease earlier in life.
The validation study will focus on typing genetic differences between individuals in the angiotensinogen gene, which encodes a protein involved in the regulation of blood pressure.

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