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a serum α2-globulin secreted in the liver which, on hydrolysis by renin, gives rise to angiotensin.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
The substrate for renin whereon through enzymatic action angiotensin I is liberated; an abundant α2-globulin that circulates in the blood plasma.
Synonym(s): angiotensin precursor
Farlex Partner Medical Dictionary © Farlex 2012
angiotensinogenA 60-kD, 1453-residue glycoprotein (13% carbohydrate) of the alpha2 globulin fraction of plasma proteins, which is synthesised and released from the liver and cleaved in the circulation to form the biologically inactive angiotensin I, a decapeptide split from the N-terminal by renin, a proteolytic enzyme.
A-I is in turn cleaved to form active A-II by ACE, which causes contraction of vascular smooth muscle and thus raises blood pressure and stimulates aldosterone release from the adrenal glands; A-III is then broken down by angiotensinases. The angiotensinogen gene is located on 1q42-43, and is mutated in essential hypertension.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
angiotensinogenRenin substrate A 60 kD glycoprotein of the α2 globulin fraction of plasma proteins, which is synthesized and released from the liver, and cleaved in the circulation to form the biologically inactive, angiotensin I, a decapeptide split from the N-terminal by renin, a proteolytic enzyme. See Angiotensin, Renin-angiotensin system.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
The substrate for renin from which through enzymatic action angiotensin I is liberated; an abundant α2-globulin that circulates in the blood plasma.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
angiotensinogenan inactive precursor of ANGIOTENSIN; it is a large protein synthesized by the liver, secreted into the bloodstream and converted into angiotensin by RENIN.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005