angiotensin-converting enzyme


Also found in: Dictionary, Thesaurus, Legal, Acronyms, Encyclopedia, Wikipedia.

angiotensin

 (ACE) [an″je-o-ten´sin]
a vasoconstrictive substance formed in the blood when renin is released from the juxtaglomerular apparatus in the kidney. The enzymatic action of renin acts on angiotensinogen to form the decapeptide angiotensin I, which is relatively inactive. It in turn is acted upon by peptidases (converting enzymes), chiefly in the lungs, to form the octapeptide angiotensin II, a powerful vasopressor and a stimulator of aldosterone secretion by the adrenal cortex. By its vasopressor action, it raises blood pressure and diminishes fluid loss in the kidney by restricting blood flow. Angiotensin II is hydrolyzed in various tissues to form heptapeptide angiotensin III, which has less vasopressor activity but more effect on the adrenal cortex.
angiotensin-converting enzyme (ACE) an enzyme of the hydrolase class that catalyzes cleavage of a dipeptide from the C-terminal end of angiotensin I to form activated angiotensin II; called also peptidyl-dipeptidase A.
angiotensin-converting enzyme inhibitors competitive inhibitors of angiotensin-converting enzyme, which converts angiotensin I to angiotensin II and inactivates bradykinin. ACE inhibitors, such as captopril, are antagonists of the renin-angiotensin-aldosterone system and potentiators of the kinin system and are used for treatment of hypertension, usually in conjunction with a diuretic. They are also used as vasodilators in the treatment of congestive heart failure.

an·gi·o·ten·sin-con·vert·ing en·zyme (ACE),

A zinc-containing hydrolase cleaving C-terminal dipeptides from a variety of substrates, including angiotensin I, which is converted to angiotensin II and histidylleucine (an important step in the metabolism of certain vasopressor agents). Drugs that inhibit it are used to treat hypertension and congestive heart failure.

angiotensin-converting enzyme

/an·gio·ten·sin-con·vert·ing en·zyme/ (-ten´sin kon-vert´ing en´zīm) see peptidyl-dipeptidase A.

angiotensin-converting enzyme (ACE)

a glycoprotein (dipeptidyl carboxypeptidase) that catalyzes the conversion of angiotensin I to angiotensin II by splitting two terminal amino acids. ACE-inhibiting agents are used for controlling hypertension and for protecting the kidneys in diabetes mellitus.

angiotensin-converting enzyme

Peptidyl-dipeptidase A is the name recommended by the IUBMB for this enzyme (EC 3.4.15.1), though it is more popularly known as angiotensin I-converting enzyme (ACE).

angiotensin-converting enzyme

A key enzyme in the RAA system, which converts the inactive decapeptide angiotensin I to the octapeptide, angiotensin II, a potent vasoconstrictor that also stimulates aldosterone secretion; ACE is also involved in metabolizing bradykinin Ref range 18–67 U/L, > age 20; those < 20 have higher levels; ACE is ↑ in sarcoidosis, Gaucher disease, leprosy, histoplasmosis, cirrhosis, asbestosis, berylliosis, DM, Hodgkin's disease, hyperthyroidism, amyloidosis, PBC, idiopathic pulmonary fibrosis, PE, scleroderma, silicosis, TB; ACE ↓ in response to prednisone therapy for sarcoidosis. See Renin/angiotensin/aldosterone system.

an·gi·o·ten·sin-con·vert·ing en·zyme

(ACE) (an'jē-ō-ten'sin-kŏn-vĕrt'ing en'zīm)
A hydrolase responsible for the conversion of angiotensin I to the vasoactive angiotensin II by removal of a dipeptide (histidylleucine) from angiotensin I. Drugs that inhibit ACE are used to treat hypertension and congestive heart failure.

angiotensin-converting enzyme

The (ACE) enzyme that converts angiotensin I to the active form angiotensin II. The gene for this enzyme has two alleles, the I allele and the D allele. Research has shown that the I allele is associated with significantly better physical performance, endurance and response to physical training than the D allele. The difference is especially marked if the I allele is present at both loci and compared with people with the D allele at both loci.

angiotensin-converting enzyme (anˑ·jē·ō·ten·sin kon·verˑ·ting enˑ·zīm),

n glycoprotein that converts angiotensin I to angiotensin II by dividing two terminal amino acids.
Enlarge picture
Angioma.
References in periodicals archive ?
Multicenter study of patients with angiotensin-converting enzyme inhibitor-induced angioedema who present to the emergency department.
Sex-dependent and race-dependent association of XPNPEP2 C-2399A polymorphism with angiotensin-converting enzyme inhibitor-associated angioedema.
Relationship between angiotensin-converting enzyme ID polymorphism and VO2max of Chinese males.
Physical activity and angiotensin-converting enzyme gene polymorphism in mild hypertensives.
Pregnancy outcome based on timing of exposure to angiotensin-converting enzyme inhibitors (ACEIs), by week of last exposure(*)--United States, Canada, and Israel, 1987-1995
One drug, an angiotensin-converting enzyme (ACE) inhibitor, has proven effective in preventing progression to stages IV and V Calcium channel blockers, another class of antihypertensive drugs, also show promise.
today announced that administration of FG-3019 alone, or in combination with angiotensin-converting enzyme inhibitor (ACEi) or angiotensin receptor blocker (ARB), was significantly better in preventing and reversing arterial stiffness than ACEi or ARB therapy alone in preclinical models of diabetes.
Good evidence exists to support the use of key secondary prevention medications (a four-drug combination of aspirin, statins, beta-blockers and angiotensin-converting enzyme inhibitors or angiotensin receptor blockers) and smoking cessation in patients after acute coronary syndromes (ACSs).
For nonblack patients with hypertension, initial treatment should be a News line thiazide-type diuretic, a calcium channel blocker (CCB), an angiotensin-converting enzyme (ACE) inhibitor, or angiotensin receptor blocker (ARB).
The study also suggested that the current use of angiotensin-converting enzyme (ACE) inhibitors was associated with a reduced incidence of both types of breast cancer.
The I alelle of the angiotensin-converting enzyme gene is associated with endurance performance; an excess occurs in elite distance runners, rowers and mountainers (G.
Clinical equivalence in generics and brand-names was seen in all trials of beta-blockers, anti-platelet agents, angiotensin-converting enzyme (ACE) inhibitors, alpha-blockers, class 1 anti-arrhythmic agents and warfarin (Coumadin), in 10 of 11 trials of diuretics and five of seven calcium-channel blocker studies.

Full browser ?