angiotensin-converting enzyme


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angiotensin

 (ACE) [an″je-o-ten´sin]
a vasoconstrictive substance formed in the blood when renin is released from the juxtaglomerular apparatus in the kidney. The enzymatic action of renin acts on angiotensinogen to form the decapeptide angiotensin I, which is relatively inactive. It in turn is acted upon by peptidases (converting enzymes), chiefly in the lungs, to form the octapeptide angiotensin II, a powerful vasopressor and a stimulator of aldosterone secretion by the adrenal cortex. By its vasopressor action, it raises blood pressure and diminishes fluid loss in the kidney by restricting blood flow. Angiotensin II is hydrolyzed in various tissues to form heptapeptide angiotensin III, which has less vasopressor activity but more effect on the adrenal cortex.
angiotensin-converting enzyme (ACE) an enzyme of the hydrolase class that catalyzes cleavage of a dipeptide from the C-terminal end of angiotensin I to form activated angiotensin II; called also peptidyl-dipeptidase A.
angiotensin-converting enzyme inhibitors competitive inhibitors of angiotensin-converting enzyme, which converts angiotensin I to angiotensin II and inactivates bradykinin. ACE inhibitors, such as captopril, are antagonists of the renin-angiotensin-aldosterone system and potentiators of the kinin system and are used for treatment of hypertension, usually in conjunction with a diuretic. They are also used as vasodilators in the treatment of congestive heart failure.

an·gi·o·ten·sin-con·vert·ing en·zyme (ACE),

A zinc-containing hydrolase cleaving C-terminal dipeptides from a variety of substrates, including angiotensin I, which is converted to angiotensin II and histidylleucine (an important step in the metabolism of certain vasopressor agents). Drugs that inhibit it are used to treat hypertension and congestive heart failure.

angiotensin-converting enzyme

Peptidyl-dipeptidase A is the name recommended by the IUBMB for this enzyme (EC 3.4.15.1), though it is more popularly known as angiotensin I-converting enzyme (ACE).

angiotensin-converting enzyme

A key enzyme in the RAA system, which converts the inactive decapeptide angiotensin I to the octapeptide, angiotensin II, a potent vasoconstrictor that also stimulates aldosterone secretion; ACE is also involved in metabolizing bradykinin Ref range 18–67 U/L, > age 20; those < 20 have higher levels; ACE is ↑ in sarcoidosis, Gaucher disease, leprosy, histoplasmosis, cirrhosis, asbestosis, berylliosis, DM, Hodgkin's disease, hyperthyroidism, amyloidosis, PBC, idiopathic pulmonary fibrosis, PE, scleroderma, silicosis, TB; ACE ↓ in response to prednisone therapy for sarcoidosis. See Renin/angiotensin/aldosterone system.

an·gi·o·ten·sin-con·vert·ing en·zyme

(ACE) (an'jē-ō-ten'sin-kŏn-vĕrt'ing en'zīm)
A hydrolase responsible for the conversion of angiotensin I to the vasoactive angiotensin II by removal of a dipeptide (histidylleucine) from angiotensin I. Drugs that inhibit ACE are used to treat hypertension and congestive heart failure.

angiotensin-converting enzyme

The (ACE) enzyme that converts angiotensin I to the active form angiotensin II. The gene for this enzyme has two alleles, the I allele and the D allele. Research has shown that the I allele is associated with significantly better physical performance, endurance and response to physical training than the D allele. The difference is especially marked if the I allele is present at both loci and compared with people with the D allele at both loci.
References in periodicals archive ?
A new method for the in vitro screening of inhibitors of angiotensin-converting enzyme (ACE), using the chromophore- and fluorophore-labelled substrate dansyltriglycine.
Binding of peptide substrates and inhibitors of angiotensin-converting enzyme. Importance of the COOH-terminal dipeptide sequence.
Angiotensin-converting enzyme gene polymorphism and vascular manifestations in Korean patients with SLE.
Fiskio et al., "An evaluation of risk factors for adverse drug events associated with angiotensin-converting enzyme inhibitors," Journal of Evaluation in Clinical Practice, vol.
This includes the enzyme angiotensin-converting enzyme 2 (ACE2) which primarily forms Ang 1-7 from Ang II, but can also form Ang 1-9 from Ang I, prolylcarboxypeptidase which also forms Ang 1-7 from Ang II, and the enzymes neprilysin and prolylendopeptidase which forms Ang 1-7 directly from Ang I, and MAS, the putative receptor for Ang 1-7.
Association study of the angiotensin-converting enzyme (ACE) gene G2350A dimorphism with myocardial infarction.
Association of angiotensin-converting enzyme (ACE) gene polymorphism with elevated serum ACE activity and major depression in an Iranian population.
Factors associated with hospitalization of patients with angiotensin-converting enzyme inhibitor-induced angioedema.
Antiglaucomatous effects of the activation of intrinsic Angiotensin-converting enzyme 2.
Sex-dependent and race-dependent association of XPNPEP2 C-2399A polymorphism with angiotensin-converting enzyme inhibitor-associated angioedema.
Most effective pharmacological treatments in heart failure, such as beta-blockers, inhibitors of angiotensin-converting enzyme, angiotensin receptor blockers, direct renin inhibitors, and mineralocorticoid receptor blockers, target the RAAS pathway.2

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